Fig. 3

The anti-tumor effects by simvastatin (SIM), atorvastatin (ATO), rosuvastatin (ROSU) and zoledronic acid (ZOL) in IGROV-1 cells are mediated by inhibited geranylgeranylation. IGROV-1 cells were treated with ATO (10 μM), SIM (10 μM), ROSU (50 μM) or ZOL (50 μM), and supplemented with 10 μM of either farnesyl pyrophosphate (FPP) or geranylgeranyl pyrophosphate (GGPP) for 48 h. a Cell vitality was assessed by CellTiterBlue® assay. b Apoptosis was measured by the Caspase 3/7 Glo® assay. Data are shown as mean ± SEM of at least three individual experiments. (*p < 0.05; **p < 0.01; ***p < 0.001 vs. respective control (C) or vs. respective treatment (−))