Fig. 3

Real time cell monitoring of OV monotherapy and combinatorial approaches. Development of tumor cell viability during the treatment. Continuous measurement of cellular impedance (Cell Index) was conducted via xCELLigence assay over 120 h. Different treatments (GLV-1 h68 infection, Triton X-100, or mock treatment) were performed at 24 h and H727 lung NET cells were employed. Tumor cells were infected with different MOIs of GLV-1 h68. GLV-1 h68 was found to exhibit dose dependent cytotoxic effects on the NET cells, showing a reduction of cellular impedance over time which was found to be pronounced with higher MOI (0.25). The experiment was carried out in quadruplicates, bars show mean and SD