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Table 5 Late postoperative outcome

From: Long term outcome of anastomotic leakage in patients undergoing low anterior resection for rectal cancer

N (%) Overall Population Symptomatic AL (SAL) Asymptomatic AL (AAL) Without AL (WAL) P
200 (100) 29 (14.5) 10 (5.0) 161 (80.5)
Oncological results
 Adjuvant chemotherapy, n (%) 52 (26.0) 7 (24.1) 1 (10.0) 44 (27.3) 0.465
Recurrence, n (%)
 Local 10 (5.0) 2 (6.9) 0 8 (5.0)  
 Distance 34 (17.0) 3 (10.3) 0 31 (19.3) 0.170
 Total patients with recurrence 39 (19.5) 4 (13.8) 0 35 (21.7)  
Time to recurrence (month), median ± IQR 10.7 (8.8–18.8) 7.0 (6.0–8.1) 0 11.8 (9.6–19.8) 0.173
Median of follow up (months) ± IQR 38.5 (17.2–65.6) 34.5 (17.1–66.5) 55.7 (28.8–61.9) 38.1 (16.7–65.5)  
Overall survival at 3 years 95.5% 82.9% 100% 94.7% 0.527
Overall survival at 5 years 91.5% 77% 100% 88.3%
Disease free survival at 3 years 81.5% 86.6% 100% 76% 0.480
Disease free survival at 5 years 80.5% 84% 100% 70%
Functional results
Permanent stoma, n (%) 31 (15.5) 13 (44.8) 3 (30.0) 15 (9.3) < 0.001
 Ileostomy 18 (9.0) 7 (24.1) 1 (10.0) 11 (6.8)  
 Colostomy 13 (6.5) 6 (20.7) 2 (20.0) 4 (2.5)  
Other late complications, n (%)      < 0.001
 Stenosis 24 6 1 17  
 Hernia 16 5 4 7  
 Occlusion 3 1 0 2  
Mean of quality of life assessments
 LARS Score 26,2 ± 12,8 34,3 ± 4,0 28,8 ± 14,9 25,1 ± 13,0 0.522
 Wexner Score 7,3 ± 4,8 10,3 ± 0,6 11,4 ± 3,8 6,4 ± 4,7 0.049
 IIEF5 10,0 ± 8,9 18,0 ± 1,4 2,3 ± 2,3 10,4 ± 9,2 0.187
 SF36 98,8 ± 10,5 105,0 ± 7,9 99,2 ± 5,4 98,2 ± 11,2 0.446
 EORTC QLQ-C30 53,9 ± 11,4 49,3 ± 3,2 62,4 ± 14,5 53,0 ± 11,0 0.077
 EuroQol 69,0 ± 18,9 75,0 ± 5,0 59,0 ± 18,2 69,9 ± 19,6 0.111
 FIQL 86,8 ± 20,6 81,3 ± 3,5 74,2 ± 22,0 89,2 ± 20,8 0.136
 EORTC QLQ-MY20 28,7 ± 7,0 28,3 ± 1,5 31,0 ± 7,1 28,4 ± 7,4 0.685
  1. AL Anastomotic leak, SAL symptomatic AL, AAL asymptomatic AL and WAL without AL, IQR interquartile range)