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Fig. 4 | BMC Cancer

Fig. 4

From: Farnesoid X receptor as marker of osteotropism of breast cancers through its role in the osteomimetism of tumor cells

Fig. 4

Treatments performed on MDA-MB-231 cell line: C = control, G = Z-guggulsterone, L = LCA, CDCA = chenodeoxycholic acid. a RUNX2, b OPN, c OC and d BSP respective expressions after different treatments. Values represent the mean percentage of mean fluorescence ± SEM of nine independent experiments. For all four markers, the percentage of fluorescence increased significantly after CDCA treatment compared to control values normalized at 100%. The inhibitor agents (LCA, Z-guggulsterone) in combination with CDCA decreased the percentage of fluorescence compared to CDCA used alone (*** p < 0.001, ** p < 0.01)

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