Table 3 Associations between neutrophil, lymphocyte, monocyte and clinical factors in HCC

Age (years)

<  60

411 (49%)

412 (48.9%)

0.149

389 (46.5%)

434 (51.4%)

0.051

391 (47.6%)

432 (50.2%)

0.305

≥ 60

427 (51%)

431 (51.1%)

447 (53.5%)

411 (48.6%)

430 (52.4%)

428 (49.8%)

Gender

Female

212 (25.3%)

134 (15.9%)

< 0.001

201 (24%)

145 (17.2%)

0.001

247 (30.1%)

99 (11.5%)

< 0.001

Male

626 (74.7%)

709 (84.1%)

635 (76%)

700 (82.8%)

574 (69.9%)

761 (88.5%)

Alcohol

No

418 (49.9%)

397 (47.1%)

0.262

463 (55.4%)

352 (41.7%)

< 0.001

468 (57%)

347 (40.3%)

< 0.001

Yes

420 (50.1%)

446 (52.9%)

373 (44.6%)

493 (58.3%)

353 (43%)

513 (59.7%)

Smoking

No

499 (59.5%)

442 (52.4%)

0.004

540 (64.6%)

401 (47.5%)

< 0.001

534 (65%)

407 (47.3%)

< 0.001

Yes

339 (40.5%)

401 (47.6%)

296 (65.4%)

444 (52.5%)

287 (35%)

453 (52.7%)

Etiology (HBV)

No

326 (38.9%)

316 (37.5%)

0.581

311 (37.2%)

331 (39.2%)

0.422

256 (31.2%)

386 (44.9%)

< 0.001

Yes

512 (61.1%)

527 (62.5%)

525 (62.8%)

514 (60.8%)

565 (68.8%)

474 (55.1%)

Tumor size (cm)

<  3.2

491 (58.6%)

285 (33.8%)

< 0.001

374 (44.7%)

402 (47.6%)

0.260

452 (55.1%)

324 (33.7%)

< 0.001

≥ 3.2

347 (41.4%)

558 (66.2%)

462 (55.3%)

443 (52.4%)

369 (44.9%)

536 (62.3%)

Tumor number

Single

570 (68%)

583 (69.2%)

0.686

565 (67.6%)

588 (69.6%)

0.401

574 (69.9%)

579 (67.3%)

0.270

Multiple

268 (32%)

260 (30.8%)

271 (32.4%)

257 (30.4%)

247 (30.1%)

281 (32.7%)

Vascular invasion

No

743 (88.7%)

625 (74.1%)

< 0.001

643 (79.9%)

725 (85.8%)

< 0.001

702 (85.5%)

666 (77.4%)

< 0.001

Yes

95 (11.3%)

218 (25.9%)

193 (23.1%)

120 (14.2%)

119 (14.5%)

194 (22.6%)

Extrahepatic metastases

No

813 (97%)

732 (86.8%)

< 0.001

758 (90.7%)

787 (93.1%)

0.073

778 (94.8%)

767 (89.2%)

< 0.001

Yes

25 (3%)

111 (13.2%)

78 (9.3%)

58 (6.9%)

43 (5.2%)

93 (10.8%)

Underlying cirrhosis

No

90 (10.7%)

160 (19%)

< 0.001

90 (10.8%)

160 (18.9%)

< 0.001

106 (12.9%)

144 (16.7%)

0.024

Yes

748 (89.3%)

683 (81%)

746 (89.2%)

685 (81.1%)

715 (87.1%)

716 (83.3%)

AFP (ng/mL)^a

<  100

520 (62.1%)

464 (55%)

0.014

450 (53.8%)

534 (62.8%)

< 0.001

500 (60.9%)

484 (56.3%)

0.347

≥ 100

271 (32.3%)

313 (37.1%)

321 (38.4%)

263 (31.1%)

282 (34.3%)

302 (35.1%)

PIVKA-II (mAU/L)^b

<  100

344 (41.1%)

230 (27.3%)

< 0.001

255 (30.5%)

319 (37.8%)

0.144

334 (40.7%)

240 (27.9%)

< 0.001

≥ 100

205 (24.5%)

310 (36.8%)

252 (30.1%)

263 (31.1%)

222 (27%)

293 (34.1%)