Table 4 Correlation between TILs and clinicopathological features in cT1N0M0 breast cancer patients undergoing SLNB
From: Prediction of lymph node metastasis by tumor-infiltrating lymphocytes in T1 breast cancer
Parameters | tumor- infiltrating lymphocytes (n = 319) | |||||
|---|---|---|---|---|---|---|
Score 0 (n = 25) | Score 1–3 (n = 294) | p value | Score 0, 1 (n = 260) | Score 2, 3 (n = 59) | p value | |
Age (years old) | ||||||
  ≤ 60 | 10 (40.0%) | 169 (57.5%) | 0.091 | 144 (55.4%) | 35 (59.3%) | 0.582 |
  > 60 | 15 (60.0%) | 125 (42.5%) | 116 (44.6%) | 24 (40.7%) | ||
Tumor size (mm) | ||||||
  ≤ 10.0 | 1 (4.0%) | 56 (19.0%) | 0.059 | 49 (18.8%) | 8 (13.6%) | 0.339 |
  > 10.0 | 24 (96.0%) | 238 (81.0%) | 211 (81.2%) | 51 (86.4%) | ||
Estrogen receptor | ||||||
 Negative | 3 (12.0%) | 54 (18.4%) | 0.425 | 29 (11.2%) | 28 (47.5%) | < 0.001 |
 Positive | 22 (88.0%) | 240 (81.6%) | 231 (88.8%) | 31 (52.5%) | ||
Progesterone receptor | ||||||
 Negative | 9 (36.0%) | 116 (39.5%) | 0.734 | 88 (33.8%) | 37 (62.7%) | < 0.001 |
 Positive | 16 (64.0%) | 178 (60.5%) | 172 (66.2%) | 22 (37.3%) | ||
Hormone receptor | ||||||
 Negative | 3 (12.0%) | 51 (17.3%) | 0.494 | 27 (10.4%) | 27 (45.8%) | < 0.001 |
 Positive | 22 (88.0%) | 243 (82.7%) | 233 (89.6%) | 32 (54.2%) | ||
HER2 | ||||||
 Negative | 24 (96.0%) | 271 (92.2%) | 0.487 | 245 (94.2%) | 50 (84.7%) | 0.013 |
 Positive | 1 (4.0%) | 23 (7.8%) | 15 (5.8%) | 9 (15.35) | ||
Ki67 | ||||||
  ≤ 14% | 19 (76.0%) | 177 (60.2%) |  | 170 (65.4%) | 26 (44.1%) |  |
  > 14% | 6 (24.0%) | 177 (39.8%) | 0.119 | 90.(34.6%) | 33 (55.9%) | 0.002 |
Lymphatic invasion | ||||||
 ly0 | 19 (56.0%) | 210 (71.4%) | 0.105 | 182 (70.0%) | 42 (71.2%) | 0.857 |
 ly1 | 11 (44.0%) | 84 (28.6%) | 78 (30.0%) | 17 (28.8%) | ||
Venous invasion | ||||||
 v0 | 25 (100.0%) | 281 (95.6%) | 0.283 | 252 (96.9%) | 54 (91.5%) | 0.058 |
 v1 | 0 (0.0%) | 13 (4.4%) | 8 (3.1%) | 5 (8.5%) | ||
Nuclear grade | Â | Â | Â | Â | Â | Â |
 1, 2 | 24 (96.0%) | 259 (88.1%) |  | 236 (90.8%) | 47 (79.7%) |  |
 3 | 1 (4.0%) | 35 (11.9%) | 0.230 | 24 (9.2%) | 12 (20.3%) | 0.015 |
Pathological lymph node metastasis | ||||||
 pN0 / pN1mic | 12 (48.0%) | 261 (88.8%) |  | 219 (84.2%) | 54 (91.5%) |  |
 pN1a / pN2 | 13 (52.0%) | 33 (11.2%) | < 0.00121 | 41 (15.8%) | 5 (8.5%) | 0.150 |