Fig. 3

Ponatinib, a multi-kinase inhibitor, inhibits colorectal cancer cell growth in vitro and in vivo. a. A high-throughput drug screening identified ponatinib as a novel therapeutic target (red dots > 50% killing; gray dots between 25 and 50% killing; black dots: < 25% killing). b. Drug sensitivity studies were performed on CRC057, CRC119 and CRC240 cell lines to determine IC50s to ponatinib. c. CRC057, CRC119 and CRC240 matched PDXs were treated orally with 30 mg/kg ponatinib five times a week