Fig. 3

The volcano plot (a) and heatmap (b) showed the distribution and top DEGs. 1219 DEGs were reveal by comparing the gene expression level between HOXA10-high and low group, with 433 upregulated DEGs and 786 downregulated DEGs. The heatmap showed the distinct expression signature of HOXA10-high (left columns) and low groups (right columns), displaying top differentially expressed genes screened by adjusted P value. The over-expressed genes were colored in red, while the under-expressed genes were in blue. The dotplot of GSEA results and barplot of ORA results were shown in c and d, respectively. In c, the significantly activated and suppressed pathways derived from GSEA were listed, in which the color of dots represent the adjusted P value and the diameter stand for enriched gene count. In d, the top enriched pathways obtained from GO/KEGG/Reactome analysis were shown, while the X axis stands for -ln(q value)