Fig. 6

Mitosis within the tumor’s body: starting from an arbitrary condition (a), a tumor cell switches to active mitotic status (b). The algorithm defines the closest bone site to the active cell by drawing a Minimum Distance Path (MDP) (c). Cells on the path are shifted of one position to make room for the newborn cell, which is placed next to the generating one (d). Finally, the newborn cell re-establishes the margin by digesting the surrounding sites (e)