Fig. 15

Tumor size-dependent growth control of PCa tumors in bone treated with Rad223. (a) Bioluminescence detection of PCa cells (PC3) over time. Mice were implanted with different doses of cancer cells in the tibia and administered with Rad223 or physiological solution (control). (b) Time-dependent therapy response expressed as the ratio of the mean bioluminescence of Rad223-treated and control groups over time (c) Example images with representative tibiae implanted with 0.10 × 10⁶ and 1.5 × 10⁶ tumor cells are shown. (d) End point histology of micro- or macro-tumors after treatment with Rad-223 (day 15). Dashed lines, tumor. Bar = 500 and 100 μm. P value by Student t test, unpaired, two-sided. Figure reproduced, with permission, from (Dondossola et al., 2019)© Oxford Academic (2019)