Table 6 Univariate and multivariate Cox regression analysis of prognostic value of clinicopathological factors and BCAT1 and CD133 expression for OS

Age at diagnosis

 ≤ 49

1

 > 49

1.295 (0.755–2.221)

Menopausal status

 Pre-menopause

1

 Post-menopause

1.081 (0.631–1.853)

Histological grade

 I/II

1

 III

0.747 (0.426–1.309)

Tumor size

 pT1

1

NA

 pT2

1.362 (0.76–2.44)

 pT3/pT4

3.975 (1.677–9.422)

Nodal status

 negative

1

1

 1–3 nodes

1.451 (0.67–3.143)

1.434 (0.660–3.114)

 4–9 nodes

2.595 (1.084–6.215)

2.904 (1.198–7.044)

 ≥ 10 nodes

6.487 (3.362–12.516)

5.780 (2.968–11.259)

TNM Stage

 I

1

NA

 II

1.794 (0.79–4.074)

 III

5.625 (2.535–12.483)

Basal-like phenotype

 Negative

1

 Positive

1.046 (0.472–2.318)

Ki67 index^a

 ≤ 14

1

NA

 > 14

0.463 (0.233–0.922)

TIL

 Low

1

1

 High

0.449 (0.25–0.808)

0.519 (0.284–0.949)

Family History

 Negative

1

 Positive

0.339 (0.047–2.452)

Chemotherapy

 Negative

1

 Positive

1.626 (0.587–4.506)

Radiotherapy

 Negative

1

NA

 Positive

1.984 (1.156–3.403)

LVI

 Negative

1

 Positive

2.06 (0.88–4.823)

BCAT1

 Low expression

1

1

 High expression

2.605 (1.519–4.467)

1.912 (1.094–3.342)

CD133

 Low expression

1

1

 High expression

2.703 (1.575–4.638)

2.554 (1.459–4.471)