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Table 4 Characteristics of patients according to DSS and OS

From: Neutrophil-lymphocyte ratio associated with poor prognosis in oral cancer: a retrospective study

Variablesn (%)5-year DSS (%)P value5-year OS (%)P value
Sex
 Male246 (56.8)83.10.684 *74.60.126 *
 Female187 (43.2)84.8 80.5 
Age
 Range (Years)22–98    
 Mean ± SD66.3 ± 13.5    
  ≥ 64173 (40.0)79.90.120 *73.70.608 *
  ≤ 65260 (60.0)86.6 79.6 
Smoking history
 No219 (50.6)88.20.548 *82.50.179 *
 Yes69 (15.9)85.3 76.7 
 Unknown145 (33.5)    
Alcohol consumption
 No152 (35.1)83.90.105 *77.30.391 *
 Yes131 (30.3)91.2 84.6 
 Unknown150 (34.6)    
Performance status
 0227 (52.4)85.20.274 *79.60.025 *
  ≥ 1202 (46.7)81.9 74.3 
 unknown4 (0.9)    
Subsite
 Tongue211 (48.7)85.40.311 *80.20.083 *
 Other222 (51.3)82.2 73.9 
T classification
 1, 2301 (69.5)88.5<  0.001 *83.1<  0.001 *
 3, 4a/b132 (30.5)72.2 62.4 
N classification
 0296 (68.4)91.6<  0.001 *85.6<  0.001 *
 Others137 (31.6)66.4 58.5 
NLR
 Low (2.22 <)233 (53.8)91.4<  0.001 *84.6< 0.001 *
 High (2.22 ≥)200 (46.2)75.5 68.8 
LMR
 Low (4.35 <)253 (58.4)76.3< 0.001 *70.00.001 *
 High (4.35 ≥)180 (41.6)89.1 82.1 
PLR
 Low (134.3 <)240 (55.4)86.60.044 *78.40.232 *
 High (134.3 ≥)193 (44.6)80.6 75.6 
Pathological status
 Pathological extra nodal metastasis     
  ENE -89 (56.3)72.80.004 *63.70.012 *
  ENE +69 (43.7)50.7 42.4 
 Number of pathological lymph node metastases
  0, 1173 (63.6)84.7< 0.001 *78.1< 0.001 *
   ≥ 299 (36.4)60.8 50.1 
 Surgical margins
  Negative314 (72.5)85.50.030 *78.70.043 *
  Involved margins112 (25.9)79.1 72.1 
  unknown7 (1.6)    
 Histological differentiation
  Well differentiated261 (60.3)91.5< 0.001 *83.30.001 *
  Moderately or poorly differentiated168 (38.8)71.7 67.0 
  unknown4 (0.9)    
  1. DSS Disease- specific survival; ENE Extranodal extension; LMR Lymphocyte-to-monocyte ratio; NLR Neutrophil-to-lymphocyte ratio; OS Overall survival; PLR Platelet-to-lymphocyte ratio
  2. *: Log-rank test