Impact of modified short-term fasting and its combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients - a controlled cross-over pilot study

Zorn, Stefanie; Ehret, Janine; Schäuble, Rebecca; Rautenberg, Beate; Ihorst, Gabriele; Bertz, Hartmut; Urbain, Paul; Raynor, Anna

doi:10.1186/s12885-020-07041-7

Table 4 Blood parameters of chemotherapy cycles with short-term fasting or normocaloric diet comparing cycles of mSTF (n = 56) with cycles of NC (n = 62)

From: Impact of modified short-term fasting and its combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients - a controlled cross-over pilot study

	Unit	NC	mSTF	PE ± SD	95% CI	P-Value
Blood count
Leukocytes	10³/μl	6.67 ± 2.23	6.09 ± 2.25	− 0.25 ± 0.30	−0.84 – 0.35	0.406
Thromobytes	10³/μl	288.2 ± 76.6	306.6 ± 76.9	4.85 ± 10.76	−16.56 – 26.25	0.654
Erythrocytes	10³/μl	3.91 ± 0.47	3.95 ± 0.37	0.11 ± 0.06	−0.01 – 0.23	0.071
Haemoglobin	g/dl	11.7 ± 1.4	11.6 ± 1.1	0.18 ± 0.18	−0.19 – 0.54	0.337
Haematocrit	%	33.5 ± 3.9	33.1 ± 2.9	0.31 ± 0.52	−0.72 – 1.33	0.553
MCH	pg	29.9 ± 1.5	29.5 ± 1.6	−0.38 ± 0.13	−0.63 – (− 0.13)	0.004
MCV	10^− 9 μl	85.7 ± 4.0	84.1 ± 3.7	−1.68 ± 0.33	−2.33 – (− 1.02)	< 0.001
MCHC	g/dl	34.9 ± 0.9	35.1 ± 0.9	0.23 ± 0.14	− 0.05 – 0.51	0.109
Neutrophils	10³/μl	4.70 ± 2.20	4.29 ± 2.24	−0.17 ± 0.30	−0.76 – 0.43	0.581
Lymphocytes	%	21.0 ± 10.7	19.7 ± 12.4	−0.89 ± 1.32	− 3.50 – 1.73	0.503
Monocytes	%	8.22 ± 4.70	10.1 ± 5.3	0.90 ± 0.72	−0.52 – 2.33	0.210
Eosinophils	%	0.71 ± 1.29	0.51 ± 1.18	−0.05 ± 0.19	−0.42 – 0.33	0.813
Basophils	%	0.68 ± 0.76	0.74 ± 0.59	−0.02 ± 0.10	−0.18 – 0.22	0.860
Electrolytes
Potassium	mmol/l	4.29 ± 0.42	4.28 ± 0.32	−0.01 ± 0.07	−0.15 – 0.12	0.845
Sodium	mmol/l	139.2 ± 2.2	137.9 ± 3.3	− 1.17 ± 0.42	− 2.0 – (− 0.33)	0.007
Calcium	mmol/l	2.33 ± 0.14	2.34 ± 0.15	0.02 ± 0.03	−0.04 – 0.07	0.561
Magnesium	mmol/l	0.80 ± 0.07	0.78 ± 0.07	−0.0 ± 0.01	−0.02 – 0.02	0.840
Liver and kidney parameters
Urea	mg/dl	26.9 ± 10.0	25.3 ± 10.6	− 1.087 – 1.34	−4.54 – 0.79	0.165
Creatinine	mg/dl	0.71 ± 0.16	0.72 ± 0.19	0.02 ± 0.01	−0.01 – 0.05	0.171
Uric acid	mg/dl	4.44 ± 1.33	5.98 ± 1.79	1.35 ± 0.17	1.01–1.68	< 0.001
Bilirubin	mg/dl	0.33 ± 0.25	0.29 ± 0.11	0.01 ± 0.03	− 0.05 – 0.07	0.305
GOT	U/l	24.2 ± 8.7	25.0 ± 7.2	1.38 ± 1.48	− 1.56 – 4.32	0.353
GPT	U/l	22.4 ± 11.8	23.5 ± 12.2	−0.10 ± 1.46	−3.01 – 2.81	0.947
AP	g/dl	71.4 ± 22.0	73.6 ± 25.0	− 1.96 ± 2.29	−6.52 – 2.58	0.392
Albumin	g/dl	4.31 ± 0.35	4.29 ± 0.32	0.02 ± 0.06	− 0.09 – 0.13	0.741
CRP	mg/l	5.57 ± 4.93	8.1 ± 13.5	0.87 ± 1.95	− 3.0 – 4.73	0.657
Hormones
TSH	μU/ml	1.05 ± 0.74	1.03 ± 0.73	−0.1 ± 0.07	−0.24 – 0.05	0.188
fT3	pmol/l	4.21 ± 0.81	3.75 ± 0.76	−0.47 ± 0.09	−0.64 – (− 0.30)	< 0.001
Ft4	pmol/l	15.5 ± 2.7	16.4 ± 2.9	0.82 ± 0.37	0.09–1.55	0.028
Insulin	pmol/l	252.7 ± 372.8	140.1 ± 252.4	− 169.4 ± 44.1	− 257.1 – (− 81.8)	< 0.001
IGF-1	ng/ml	127.7 ± 55.7	97.8 ± 46.4	− 33.3 ± 5.4	−44.1 – (− 22.5)	< 0.001

Values are shown as mean ± SD. Due to missing data, we included data of 61 cycles of NC and 56 cycles of mSTF in this analysis. Abbreviations: AP alkaline phosphatase, CRP C-reactive protein, GOT glutamic-oxaloacetic transaminase, GPT glutamic-pyruvic transaminase, IGF-1 insulin-like growth factor 1, MCH mean corpuscular haemoglobin, MCHC mean corpuscular haemoglobin concentration, MCV mean corpuscular volume, fT3 free triiodothyronine, fT4 free thyroxine, TSH thyroid stimulating hormone

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