High risk 2 | Regional metastases | Distant metastases | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Controls (N) | Cases (N) | OR | 95% CI | Controls (N) | Cases (N) | OR | 95% CI | Controls (N) | Cases (N) | OR | 95% CI | |
T2DM | ||||||||||||
no DM | 24,746 | 5081 | Ref | 6772 | 1398 | Ref | 15,031 | 3084 | Ref | |||
T2DM | 5333 | 1011 | 0.93 | (0.87–1.00) | 1519 | 282 | 0.9 | (0.78–1.04) | 3232 | 617 | 0.91 | (0.82–1.00) |
Duration of T2DM (years) | ||||||||||||
no DM | 24,746 | 5081 | Ref | 6772 | 1398 | Ref | 15,031 | 3084 | Ref | |||
< 1 | 257 | 67 | 1.28 | (0.97–1.68) | 92 | 15 | 0.76 | (0.43–1.35) | 158 | 44 | 1.33 | (0.95–1.87) |
1 - < 5 | 1122 | 224 | 0.99 | (0.85–1.14) | 350 | 62 | 0.87 | (0.66–1.15) | 712 | 117 | 0.8 | (0.65–0.97) |
5 - < 10 | 1453 | 281 | 0.95 | (0.83–1.08) | 396 | 68 | 0.84 | (0.64–1.09) | 816 | 158 | 0.87 | (0.73–1.04) |
10 - < 20 | 1727 | 316 | 0.9 | (0.80–1.02) | 467 | 94 | 0.97 | (0.77–1.22) | 1078 | 201 | 0.89 | (0.76–1.04) |
20 | 774 | 123 | 0.77 | (0.63–0.94) | 214 | 43 | 0.96 | (0.69–1.35) | 423 | 97 | 1.06 | (0.84–1.32) |
Duration of Insulin (years) | ||||||||||||
no DM | 24,746 | 5081 | Ref | 6772 | 1398 | Ref | 15,031 | 3084 | Ref | |||
0.5 - < 3 | 509 | 80 | 0.77 | (0.60–0.98) | 150 | 16 | 0.52 | (0.31–0.88) | 317 | 64 | 0.9 | (0.68–1.19) |
3 - < 5 | 291 | 46 | 0.85 | (0.63–1.16) | 86 | 17 | 0.97 | (0.57–1.65) | 197 | 35 | 0.83 | (0.58–1.20) |
5 | 971 | 169 | 0.86 | (0.72–1.01) | 270 | 50 | 0.88 | (0.64–1.21) | 588 | 120 | 0.96 | (0.78–1.18) |
Missing | 3562 | 713 | 1013 | 199 | 2130 | 398 | ||||||
Duration of high-dose Metformin (years) | ||||||||||||
no DM | 24,746 | 5081 | Ref | 6772 | 1398 | Ref | 15,031 | 3084 | Ref | |||
0.5 - < 3 | 1290 | 235 | 0.89 | (0.77–1.03) | 367 | 66 | 0.87 | (0.66–1.15) | 761 | 134 | 0.84 | (0.69–1.02) |
3 - < 5 | 508 | 97 | 0.96 | (0.77–1.20) | 125 | 33 | 1.23 | (0.82–1.83) | 291 | 55 | 0.89 | (0.67–1.20) |
5 | 408 | 95 | 1.19 | (0.94–1.50) | 112 | 23 | 0.96 | (0.61–1.52) | 231 | 58 | 1.25 | (0.93–1.68) |
Missing | 3127 | 584 | 915 | 160 | 1949 | 370 | ||||||
Duration of low-dose Metformin (years) | ||||||||||||
no DM | 24,746 | 5081 | Ref | 6772 | 1398 | Ref | 15,031 | 3084 | Ref | |||
0.5 - < 3 | 1966 | 385 | 0.97 | (0.86–1.09) | 552 | 101 | 0.89 | (0.71–1.12) | 1200 | 223 | 0.86 | (0.74–1.00) |
3 - < 5 | 891 | 152 | 0.85 | (0.72–1.02) | 228 | 48 | 1 | (0.73–1.38) | 515 | 87 | 0.81 | (0.64–1.02) |
5 | 428 | 86 | 0.97 | (0.76–1.23) | 124 | 33 | 1.44 | (0.97–2.15) | 292 | 54 | 0.87 | (0.65–1.17) |
Missing | 2048 | 388 | 615 | 100 | 1225 | 253 | ||||||
Duration of SU (years) | ||||||||||||
no DM | 24,746 | 5081 | Ref | 6772 | 1398 | Ref | 15,031 | 3084 | Ref | |||
0.5 - < 3 | 559 | 81 | 0.7 | (0.55–0.88) | 151 | 29 | 0.89 | (0.58–1.36) | 349 | 60 | 0.83 | (0.62–1.09) |
3 - < 5 | 302 | 54 | 0.85 | (0.63–1.15) | 78 | 15 | 0.95 | (0.53–1.70) | 187 | 29 | 0.65 | (0.43–0.98) |
5 | 469 | 69 | 0.74 | (0.57–0.96) | 128 | 22 | 0.81 | (0.51–1.28) | 285 | 63 | 1.07 | (0.81–1.42) |
Missing | 4003 | 807 | 1162 | 216 | 2411 | 465 |