Table 3 Multivariable survival analysis to identify factors predicting OS by using multivariable Cox regression models a Before propensity matching

Factor

HR

95%CI

P value

GC type

 non-HAS

-

-

-

 HAS

1.193

0.596 -2.386

0.619

Age (yr)

0.463

 <45

-

-

-

 60>age≥45

1.113

0.621-1.993

0.720

 ≥60

1.335

0.752-2.372

0.324

Location

0.978

 U

-

-

-

 M

1.000

0.628-1.594

0.999

 L

1.031

0.573-1.857

0.918

 T

1.304

0.392-4.334

0.665

Surgery type

0.152

 PG

-

-

-

 DG

1.096

0.137-8.782

0.931

 TG

1.805

0.242-13.456

0.564

 TGC

4.924

0.407-59.619

0.210

Vascular invasion

 no

-

-

 yes

1.145

0.771-1.701

0.503

T

<0.001

 Tis,T0,T1,T2

-

-

-

 T3

1.930

0.939-3.967

0.074

 T4

3.518

1.756-7.050

<0.001

N

0.001

 N0

-

-

-

 N1

1.945

0.983-3.847

0.056

 N2

2.133

1.070-4.252

0.031

 N3

3.579

1.839-6.966

<0.001

CEA (ng/ml)

 ≤5

-

-

-

 >5

1.460

0.992-2.151

0.055

CA199 (u/ml)

 ≤37

-

-

-

 >37

1.514

0.998-2.297

0.051

EGFR

0.046

 -

-

-

-

 +

1.342

0.788-2.286

0.279

 ++

0.766

0.399-1.468

0.422

 +++

0.786

0.411-1.503

0.467

 no

-

-

-

 yes

1.724

1.123-2.646

0.013

Factor

HR

95%CI

P

GC type

 non-HAS

-

-

-

 HAS

1.114

0.390-3.183

0.841

Age (yr)

0.158

 <45

-

-

-

 60>age≥45

1.103

0.120-10.169

0.931

 ≥60

2.716

0.322-22.934

0.359

 no

-

-

-

 yes

4.633

0.936-22.942

0.060

T

0.049

 Tis,T0,T1,T2

-

-

-

 T3

3.779

0.674-21.186

0.131

 T4

8.435

1.408-50.544

0.020

N

0.241

 N0

-

-

-

 N1

0.113

0.014-0.921

0.042

 N2

0.233

0.033-1.668

0.147

 N3

0.198

0.024-1.659

0.136

 M0

-

-

-

 M1

7.354

1.760-30.737

0.006

 ≤5

 >5

3.123

1.276-7.643

0.013

 ≤37

 >37

4.275

0.759-24.071

0.099

EGFR

0.030

 -

-

-

-

 +

0.115

0.010-1.347

0.085

 ++

0.028

0.002-0.375

0.007

 +++

0.101

0.009-1.159

0.066

 no

-

-

-

 yes

3.816

1.339-10.878

0.012

Factor

HR

95%CI

P

 non-HAS

-

-

-

 HAS

2.579

0.839-7.925

0.098

Age (yr)

0.306

 <45

-

-

-

 60>age≥45

5.503

0.159-190.915

0.346

 ≥60

9.580

0.304-301.867

0.199

 no

-

-

-

 yes

2.597

0.472-14.281

0.273

T

0.207

 Tis,T0,T1,T2

-

-

-

 T3

5.591

0.775-40.367

0.088

 T4

6.032

0.732-49.721

0.095

N

0.640

 N0

-

-

-

 N1

0.637

0.072-5.636

0.685

 N2

0.355

0.036-3.515

0.376

 N3

0.912

0.111-7.474

0.932

 M0

-

-

-

 M1

51.522

2.359-1125.341

0.012

CEA (ng/ml)

-

 ≤5

-

-

 >5

8.116

2.294-28.719

0.001

 ≤37

 >37

0.000

0.000-

0.983

EGFR

0.214

 -

-

-

-

 +

0.150

0.014-1.587

0.115

 ++

0.094

0.009-0.929

0.043

 +++

0.136

0.019-0.996

0.050

 no

-

-

-

 yes

2.717

0.729-10.131

0.137