Table 1 Correlation of VDR and FOXP3 immunohistochemical expression and clinical data in classic Hodgkin lymphoma
Clinical Features | VDR and FOXP3 Diffuse N(%) | VDR and FOXP3 Focal/Absent N(%) | VDR Diffuse and FOXP3 Focal/Absent N(%) | VDR focal/absent and FOXP3 diffuse N(%) | Total N(%) | P Value a |
|---|---|---|---|---|---|---|
Age (years) | ||||||
  > 45 | 2 (22.2) | 7 (77.8) | 0 | 0 | 9 (100) | 0.3 |
  ≤ 45 | 7 (35) | 10 (50) | 0 | 3 (15) | 20 (100) |  |
Gender | ||||||
 Male | 4 (19) | 15 (71.4) | 0 | 2 (9.5) | 21 (100) | 0.02* |
 Female | 5 (62.5) | 2 (25) | 0 | 1 (12.5) | 8 (100) |  |
B Symptoms | ||||||
 Present | 6 (35.2) | 9 (52.9) | 0 | 2 (11.7) | 17 (100) | > 0.9 |
 Absent | 2 (25) | 5 (62.5) | 0 | 1 (12.5) | 8 (100) |  |
Unknown | 1 (25) | 3 (75) | 0 | 0 | 4 (100) | Â |
Ann Arbor Stage | ||||||
 I/IIA | 4 (50) | 4 (50) | 0 | 0 | 8 (100) | 0.4 |
 IIB/III/IV | 5 (27.7) | 10 (55.5) | 0 | 3 (16.6) | 18 (100) |  |
Unknown | 0 | 3 (100) | 0 | 0 | 3 (100) | Â |
IPS Score | ||||||
 0–2 | 3 (37.5) | 3 (37.5) | 0 | 2 (25) | 8 (100) | 0.3 |
 3–7 | 2 (18.1) | 8 (72.7) | 0 | 1 (9) | 11 (100) |  |
Unknown | 0 | 1 (100) | 0 | 0 | 1 (100) | Â |
Extranodal involvement | ||||||
 YES | 3 (21.4) | 10 (71.4) | 0 | 1 (7.1) | 14 (100) | 0.2 |
 NO | 6 (46.1) | 5 (38.5) | 0 | 2 (15.4) | 13 (100) |  |
Unknown | 0 | 2 (100) | 0 | 0 | 2 (100) | Â |
Histopathology | ||||||
 NS | 7 (36.8) | 9 (47.4) | 0 | 3 (15.8) | 19 (100) | 0.6 |
 MC | 1 (20) | 4 (80) | 0 | 0 | 5 (100) |  |
 LR | 1 (100) | 0 | 0 | 0 | 1 (100) | NA |
NOS | 0 | 4 (100) | 0 | 0 | 4 (100) | NA |
Bone Marrow Involvement | ||||||
 Yes | 0 | 5 (100) | 0 | 0 | 5 (100) | 0.053 |
 No | 9 (45) | 8 (40) | 0 | 3 (15) | 20 (100) |  |
Not evaluated | 0 | 4 (100) | 0 | 0 | 4 (100) | Â |
EBER | ||||||
 Positive | 1 (20) | 4 (80) | 0 | 0 | 5 (100) | > 0.9 |
 Negative | 6 (30) | 12 (60) | 0 | 2 (10) | 20 (100) |  |
 Not evaluated | 2 (50) | 1 (25) | 0 | 1 (25) | 4 (100) |  |
Remission after first-line treatment | ||||||
 Yes | 7 (36.8) | 10 (52.6) | 0 | 2 (10.5) | 19 (100) | > 0.9 |
 No | 2 (33.3) | 3 (50) | 0 | 1 (16.7) | 6 (100) |  |
 Unknown | 0 | 4 (100) | 0 | 0 | 4 (100) |  |
Outcome at the end of observation | ||||||
 Alive | 5 (31.2) | 8 (50) | 0 | 3 (18.8) | 16 (100) | > 0.9 |
 Dead | 1 (25) | 3 (75) | 0 | 0 | 4 (100) |  |
Unknown | 3 (33.3) | 6 (66.7) | 0 | 0 | 9 (100) | Â |