Whole-brain irradiation with hippocampal sparing and dose escalation on metastases: neurocognitive testing and biological imaging (HIPPORAD) – a phase II prospective randomized multicenter trial (NOA-14, ARO 2015–3, DKTK-ROG)

Table 3 Planning target volume (PTV) – specifications for total dose (PTV_WB-A = Planning target volume of the whole brain in arm A, PTV_WB-B = Planning target volume of the whole brain in arm B, PTV_met = Planning target volume of metastases, PTV_res = Planning target volume of resection cavity)

Parameter	Per Protocol	Minor Deviation	Major Deviation
PTV_{WB-A or -B}	D_98% ≥ 25Gy D_mean ≤ 35 Gy	24Gy ≤ D_98% < 25Gy 35Gy < D_mean ≤ 37 Gy	D_98% < 24Gy D_mean > 37 Gy
PTV_{met 51Gy (brain metastases)}	D_98% ≥ 48.4Gy D_2% ≤ 63.7Gy	47.4Gy ≤ D_98% < 48.4Gy 63.7Gy < D_2% ≤ 66.3Gy	D_98% < 47.4Gy D_2% > 66.3Gy
PTV_{met 42Gy} (brain stem metastases) PTV_{res 42Gy}	D_98% ≥ 39.9Gy D_2% ≤ 52.5 Gy	39.06 Gy ≤ D_98% < 39.9Gy 52.5 Gy < D_2% ≤ 54.6 Gy	D_98% < 39.06 D_2% > 54.6 Gy

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