Table 2 Multivariate analyses of prognostic factors for OS of stage III gastric cancer
Variables | Analysis with CAR | Analysis with NLR | Analysis with PLR | Analysis with PNI | Analysis with GPS | |||||
|---|---|---|---|---|---|---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
Age (years) | ||||||||||
≤ 68 | 1 | 1 | 1 | 1 | 1 | |||||
> 68 | 1.245 (0.832–1.862) | 0.287 | 1.303 (0.878–1.935) | 0.189 | 1.354 (0.910–2.014) | 0.135 | 1.284 (0.851–1.937) | 0.234 | 1.298 (0.871–1.934) | 0.200 |
Performance status | ||||||||||
0 | 1 | 1 | 1 | 1 | 1 | |||||
1–3 | 1.246 (0.793–1.957) | 0.340 | 1.311 (0.843–2.039) | 0.229 | 1.320 (0.852–2.046) | 0.214 | 1.333 (0.857–2.073) | 0.202 | 1.318 (0.847–2.051) | 0.221 |
Location | ||||||||||
Upper/Middle/Lower | 1 | 1 | 1 | 1 | 1 | |||||
Whole | 1.097 (0.882–1.364) | 0.406 | 1.079 (0.866–1.345) | 0.497 | 1.079 (0.867–1.343) | 0.496 | 1.095 (0.880–1.362) | 0.417 | 1.090 (0.876–1.358) | 0.439 |
Operative procedure | ||||||||||
Distal gastrectomy | 1 | 1 | 1 | 1 | 1 | |||||
Total gastrectomy | 1.765 (1.201–2.595) | 0.004 | 1.657 (1.138–2.413) | 0.008 | 1.753 (1.195–2.573) | 0.004 | 1.654 (1.132–2.417) | 0.009 | 1.660 (1.136–2.425) | 0.009 |
TNM sub-stage | ||||||||||
IIIA | 1 | 0.060 | 1 | 0.048 | 1 | 0.034 | 1 | 0.066 | 1 | 0.063 |
IIIB | 1.511 (0.972–2.348) | 0.067 | 1.481 (0.953–2.300) | 0.081 | 1.531 (0.983–2.382) | 0.059 | 1.487 (0.953–2.321) | 0.081 | 1.495 (0.962–2.323) | 0.074 |
IIIC | 1.694 (1.074–2.671) | 0.023 | 1.754 (1.111–2.768) | 0.016 | 1.812 (1.146–2.865) | 0.011 | 1.707 (1.074–2.714) | 0.024 | 1.702 (1.074–2.697) | 0.024 |
Tumor size (mm) | ||||||||||
≤ 60 | 1 | 1 | 1 | 1 | 1 | |||||
> 60 | 1.017 (0.689–1.501) | 0.933 | 1.065 (0.726–1.561) | 0.749 | 0.983 (0.663–1.457) | 0.931 | 1.058 (0.717–1.561) | 0.776 | 1.054 (0.715–1.554) | 0.791 |
Adjuvant chemotherapy | ||||||||||
Absent | 1 | 1 | 1 | 1 | 1 | |||||
Present | 0.807 (0.507–1.284) | 0.366 | 0.810 (0.509–1.288) | 0.373 | 0.772 (0.486–1.227) | 0.274 | 0.797 (0.501–1.267) | 0.337 | 0.806 (0.508–1.281) | 0.361 |
CAR | ||||||||||
Low (≤0.47) | 1 | |||||||||
High (> 0.47) | 2.257 (1.180–4.319) | 0.014 | ||||||||
NLR | ||||||||||
Low (≤1.90) | 1 | |||||||||
High (> 1.90) | 1.322 (0.926–1.887) | 0.124 | ||||||||
PLR | ||||||||||
Low (≤172) | 1 | |||||||||
High (> 172) | 1.478 (1.025–2.133) | 0.037 | ||||||||
PNI | ||||||||||
Low (≤45.6) | 1 | |||||||||
High (> 45.6) | 0.922 (0.631–1.348) | 0.676 | ||||||||
GPS | ||||||||||
0 | 1 | |||||||||
1/2 | 1.141 (0.754–1.727) | 0.533 | ||||||||