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Table 2 Multivariate analyses of prognostic factors for OS of stage III gastric cancer

From: Clinical significance of prognostic inflammation-based and/or nutritional markers in patients with stage III gastric cancer

VariablesAnalysis with CARAnalysis with NLRAnalysis with PLRAnalysis with PNIAnalysis with GPS
HR (95% CI)p valueHR (95% CI)p valueHR (95% CI)p valueHR (95% CI)p valueHR (95% CI)p value
Age (years)
  ≤ 681 1 1 1 1 
  > 681.245 (0.832–1.862)0.2871.303 (0.878–1.935)0.1891.354 (0.910–2.014)0.1351.284 (0.851–1.937)0.2341.298 (0.871–1.934)0.200
Performance status
 01 1 1 1 1 
 1–31.246 (0.793–1.957)0.3401.311 (0.843–2.039)0.2291.320 (0.852–2.046)0.2141.333 (0.857–2.073)0.2021.318 (0.847–2.051)0.221
Location
 Upper/Middle/Lower1 1 1 1 1 
 Whole1.097 (0.882–1.364)0.4061.079 (0.866–1.345)0.4971.079 (0.867–1.343)0.4961.095 (0.880–1.362)0.4171.090 (0.876–1.358)0.439
Operative procedure
 Distal gastrectomy1 1 1 1 1 
 Total gastrectomy1.765 (1.201–2.595)0.0041.657 (1.138–2.413)0.0081.753 (1.195–2.573)0.0041.654 (1.132–2.417)0.0091.660 (1.136–2.425)0.009
TNM sub-stage
 IIIA10.06010.04810.03410.06610.063
 IIIB1.511 (0.972–2.348)0.0671.481 (0.953–2.300)0.0811.531 (0.983–2.382)0.0591.487 (0.953–2.321)0.0811.495 (0.962–2.323)0.074
 IIIC1.694 (1.074–2.671)0.0231.754 (1.111–2.768)0.0161.812 (1.146–2.865)0.0111.707 (1.074–2.714)0.0241.702 (1.074–2.697)0.024
Tumor size (mm)
  ≤ 601 1 1 1 1 
  > 601.017 (0.689–1.501)0.9331.065 (0.726–1.561)0.7490.983 (0.663–1.457)0.9311.058 (0.717–1.561)0.7761.054 (0.715–1.554)0.791
Adjuvant chemotherapy
 Absent1 1 1 1 1 
 Present0.807 (0.507–1.284)0.3660.810 (0.509–1.288)0.3730.772 (0.486–1.227)0.2740.797 (0.501–1.267)0.3370.806 (0.508–1.281)0.361
CAR
 Low (≤0.47)1         
 High (> 0.47)2.257 (1.180–4.319)0.014        
NLR
 Low (≤1.90)  1       
 High (> 1.90)  1.322 (0.926–1.887)0.124      
PLR
 Low (≤172)    1     
 High (> 172)    1.478 (1.025–2.133)0.037    
PNI
 Low (≤45.6)      1   
 High (> 45.6)      0.922 (0.631–1.348)0.676  
GPS
 0        1 
 1/2        1.141 (0.754–1.727)0.533
  1. TNM tumor-node-metastasis, CAR C-reactive protein/Albumin ratio, NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, PNI Prognostic Nutritional Index, GPS Glasgow Prognostic Score