Fig. 1

Genetic lineage and GM colonization additively determine adenoma numbers in ApcMin mice. a Embryos from the Min/J and Min/D genetic lineages were transplanted into surrogate dams harboring two distinct complex GM profiles; GMJAX and GMHSD. Offspring represent the two genetic lineages which have inherited a GM from their respective surrogate dams (Min/J_GMJAX,n = 13; Min/D_GMJAX,n = 18; Min/J_GMHSD,n = 19; Min/D_GMHSD, n = 10). b Scatter plots comparing mean (± SEM) small intestinal (SI) and colon adenoma counts of the original B6-Apc^Min colony generated at UW McArdle Laboratory (Min/D) to B6-Apc^Min mice acquired from The Jackson Laboratory and maintained at University of Missouri (Min/J) (Min/D, n = 65; Min/J, n = 22). c Scatter plots comparing mean (± SEM) SI and colon adenoma counts of the four rederived groups, including each genetic lineage (Min/J and Min/D) rederived with two complex GMs. *p < 0.05, **p < 0.01, ***P < 0.001; Student’s t-test (a) and Two-way ANOVA with the Student Newman-Keuls method (c)