Augmenting cancer registry data with health survey data with no cases in common: the relationship between pre-diagnosis health behaviour and post-diagnosis survival in oesophageal cancer

Fahey, Paul P.; Page, Andrew; Stone, Glenn; Astell-Burt, Thomas

doi:10.1186/s12885-020-06990-3

Table 3 Estimated relative risks of 1-year survival derived from imputed pre-diagnosis behaviours for SEER oesophageal cancer cases, 2006–2014; unadjusted and age adjusted

From: Augmenting cancer registry data with health survey data with no cases in common: the relationship between pre-diagnosis health behaviour and post-diagnosis survival in oesophageal cancer

	Imputed RR (RR_i)		Impossible Result (RR_i < 0)	Estimated True RR (RR_T)		Age-adjusted Imputed RR (adjRR_i)		Impossible Result (adjRR_i < 0)	Age-adjusted Estimated True RR (adjRR_T)
	Median	95% CI	Frequency	Median	95% CI	Median	95% CI	Frequency	Median	95% CI
Current smoking
All	0.986	0.954,1.009	0	0.806	0.380,1.130	1.051	1.014,1.078	0	1.794	1.215,2.357^a
ESCC	1.025	0.981,1.067	0	1.349	0.733,2.142	1.064	1.016,1.111	0	1.990	1.240,3.117 ^a
EAC	0.959	0.914,1.000 ^a	5	0.478	0.039,1.003 ^b	1.038	0.985,1.085	0	1.613	0.785,2.571
Binge drinking
All	0.933	0.900,0.964	49	failed	failed	0.997	0.961,1.032	1	0.951	0.445,1.539 ^b
ESCC	0.998	0.936,1.059	4	0.991	0.167,1.995 ^b	1.033	0.968,1.101	0	1.515	0.440,2.754
EAC	0.914	0.863,0.961 ^a	72	failed	failed	0.989	0.935,1.046	3	0.818	0.181,1.890 ^b
Heavy drinking
All	0.981	0.932,1.028	61	failed	failed	1.010	0.963,1.060	23	failed	failed
ESCC	0.995	0.912,1.066	48	failed	failed	1.012	0.929,1.088	36	failed	failed
EAC	0.974	0.907,1.039	66	failed	failed	1.011	0.938,1.077	35	failed	failed
Physical activity
All	0.954	0.934,0.978 ^a	0	0.319	0.165,0.564 ^a	0.974	0.956,1.001	0	0.507	0.307,1.030
ESCC	0.959	0.925,0.991	2	0.345	0.073,0.811 ^a,b	0.971	0.933,1.003	1	0.452	0.102,1.071^b
EAC	0.957	0.929,0.986 ^a	1	0.311	0.109,0.675 ^a,b	0.984	0.954,1.013	0	0.627	0.285,2.180
Obese
All	0.969	0.946,0.993 ^a	24	failed	failed	1.008	0.983,1.036	0	1.262	0.559,2.931
ESCC	1.000	0.968,1.039	0	1.004	0.134,2.378	1.027	0.992,1.068	0	1.733	0.834,4.167
EAC	0.949	0.917,0.987 ^a	76	failed	failed	0.996	0.960,1.035	8	failed	failed
Current smoking with regular drinking
All	0.987	0.930,1.058	40	failed	failed	1.044	0.986,1.120	2	3.254	0.771,11.843 ^b
ESCC	1.044	0.946,1.146	12	failed	failed	1.076	0.973,1.180	11	failed	failed
EAC	0.963	0.861,1.052	60	failed	failed	1.032	0.919,1.123	13	failed	failed

Imputed RR (RR_i) – the relative risk calculated using the imputed behaviour
Impossible result – instances where the estimated true relative risk was impossible (a negative value)
Estimated True RR (RR_T) – the estimated true relative risk derived from the imputed relative risk and calibration parameters \( \hat{p_i} \) and \( \hat{\rho} \)
Median median of 100 repetitions of the imputation algorithm,
95% CI = empirical 95% confidence interval created from the 2.5 and 97.5 percentiles obtained from 100 repetitions of the imputation algorithm,
^a 95% confidence intervals exclude no association (i.e. exclude relative risk equals 1)
^b excludes impossible result

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ISSN: 1471-2407

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