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Table 3 Risk factors associated with postoperative disease free survival and overall survival identified by univariate Cox regression analysis in the entire cohort

From: Perioperative blood transfusion has distinct postsurgical oncologic impact on patients with different stage of hepatocellular carcinoma

Variables

Univariate Analysis

Overall survival

Disease-free survival

Hazard ratio

p-valule

Hazard ratio

p-value

Age, year

  ≤ 50 vs > 50

0.991 (0.983–0.999)

0.025

0.715

(0.617–0.829)

< 0.001

Sex

 Male vs female

0.953 (0.710–1.278)

0.746

0.789

(0.622–0.999)

0.049

HbsAg

 Positive vs negative

1.013 (0.777–1.320)

0.924

1.049

(0.855–1.288)

0.646

Cirrhosis

 Yes vs no

1.230 (0.990–1.529)

0.062

1.325

(1.119–1.568)

0.001

ALBI grade

 2 + 3 vs 1

1.561 (1.291–1.886)

< 0.0001

1.218

(1.052–1.409)

0.008

ALT, U/L

  > 40 vs ≤ 40

1.199 (0.987–1.457)

0.068

1.254

(1.082–1.455)

0.003

Platelet. ×109/L

  ≤ 100 vs > 100

1.007 (0.690–1.469)

0.972

1.083(0.810–1.448)

0.590

NLR

  > 2.3 vs ≤ 2.3

1.102 (1.070–1.134)

< 0.001

1.058(1.030–1.087)

< 0.001

PLR

  > 118.9 vs ≤ 118.9

1.002 (1.000–1.003)

< 0.001

1.002

(1.001–1.002)

< 0.001

APRI

  > 0.55 vs ≤ 0.55

0.934 (0.724–1.206)

0.601

1.001

(0.847–1.184)

0.988

Tumor size, cm

  > 5.0 vs ≤ 5.0

2.353 (1.792–3.090)

< 0.001

1.832(1.523–2.204)

< 0.001

Tumor number

 Multiple vs solitary

1.906 (1.554–2.336)

< 0.001

1.768

(1.432–2.183)

< 0.001

Tumor capsule

 Incomplete vs complete

0.474 (0.382–0.588)

< 0.001

0.587

(0.494–0.698)

< 0.001

Differentiation

 3 + 4 vs 1 + 2

1.170 (0.948–1.443)

0.145

1.183

(1.007–1.389)

0.041

Macro-VTT

 Yes vs no

3.295 (2.660–4.083)

< 0.001

2.411

(2.026–2.869)

< 0.001

MVI

 Yes vs no

2.347 (1.925–2.860)

< 0.001

1.944

(1.664–2.270)

< 0.001

AFP, μg/L

  > 400 vs ≤ 400

1.841(1.516–2.236)

< 0.001

1.608

(1.386–1.864)

< 0.001

Resection margin, cm

  ≤ 1.0 vs > 1.0

1.050 (0.998–1.521)

0.354

0.865 (0.775–1.211)

0.746

Pringle maneuver

 Yes vs no

0.886 (0.815–0.956)

0.234

0.786 (0.705–0.898)

0.846

Resection type

 Anatomic vs nonanatomic

1.366 (1.125–1.660)

0.02

1.375 (1.185–1.595)

< 0.001

Resection extent

 Major vs minor

1.728 (1.422–2.099)

< 0.001

1.702 (1.468–1.974)

< 0.001

Blood loss, ml

  > 800 vs ≤ 800

2.217(1.807–2.720)

< 0.001

1.761(1.494–2.075)

< 0.001

Blood transfusion

 Yes vs no

2.107 (1.726–2.571)

< 0.001

1.759 (1.503–2.058)

< 0.001

  1. Abbreviation: HBsAg hepatitis B virus surface antigen, ALT anlanine transaminase, NLR indicates neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, APRI alanine transaminase to platelet ratio index, AFP alpha fetoprotein, MVI microscopic vascular invasion, Macro-VTT macroscopic venous tumor thrombus, including portal vein tumor thrombus and hepatic vein tumor thrombus
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BMC Cancer

ISSN: 1471-2407

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