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Table 3 Risk factors associated with postoperative disease free survival and overall survival identified by univariate Cox regression analysis in the entire cohort

From: Perioperative blood transfusion has distinct postsurgical oncologic impact on patients with different stage of hepatocellular carcinoma

VariablesUnivariate Analysis
Overall survivalDisease-free survival
Hazard ratiop-valuleHazard ratiop-value
Age, year
  ≤ 50 vs > 500.991 (0.983–0.999)0.0250.715(0.617–0.829)< 0.001
Sex
 Male vs female0.953 (0.710–1.278)0.7460.789(0.622–0.999)0.049
HbsAg
 Positive vs negative1.013 (0.777–1.320)0.9241.049(0.855–1.288)0.646
Cirrhosis
 Yes vs no1.230 (0.990–1.529)0.0621.325(1.119–1.568)0.001
ALBI grade
 2 + 3 vs 11.561 (1.291–1.886)< 0.00011.218(1.052–1.409)0.008
ALT, U/L
  > 40 vs ≤ 401.199 (0.987–1.457)0.0681.254(1.082–1.455)0.003
Platelet. ×109/L
  ≤ 100 vs > 1001.007 (0.690–1.469)0.9721.083(0.810–1.448)0.590
NLR
  > 2.3 vs ≤ 2.31.102 (1.070–1.134)< 0.0011.058(1.030–1.087)< 0.001
PLR
  > 118.9 vs ≤ 118.91.002 (1.000–1.003)< 0.0011.002(1.001–1.002)< 0.001
APRI
  > 0.55 vs ≤ 0.550.934 (0.724–1.206)0.6011.001(0.847–1.184)0.988
Tumor size, cm
  > 5.0 vs ≤ 5.02.353 (1.792–3.090)< 0.0011.832(1.523–2.204)< 0.001
Tumor number
 Multiple vs solitary1.906 (1.554–2.336)< 0.0011.768(1.432–2.183)< 0.001
Tumor capsule
 Incomplete vs complete0.474 (0.382–0.588)< 0.0010.587(0.494–0.698)< 0.001
Differentiation
 3 + 4 vs 1 + 21.170 (0.948–1.443)0.1451.183(1.007–1.389)0.041
Macro-VTT
 Yes vs no3.295 (2.660–4.083)< 0.0012.411(2.026–2.869)< 0.001
MVI
 Yes vs no2.347 (1.925–2.860)< 0.0011.944(1.664–2.270)< 0.001
AFP, μg/L
  > 400 vs ≤ 4001.841(1.516–2.236)< 0.0011.608(1.386–1.864)< 0.001
Resection margin, cm
  ≤ 1.0 vs > 1.01.050 (0.998–1.521)0.3540.865 (0.775–1.211)0.746
Pringle maneuver
 Yes vs no0.886 (0.815–0.956)0.2340.786 (0.705–0.898)0.846
Resection type
 Anatomic vs nonanatomic1.366 (1.125–1.660)0.021.375 (1.185–1.595)< 0.001
Resection extent
 Major vs minor1.728 (1.422–2.099)< 0.0011.702 (1.468–1.974)< 0.001
Blood loss, ml
  > 800 vs ≤ 8002.217(1.807–2.720)< 0.0011.761(1.494–2.075)< 0.001
Blood transfusion
 Yes vs no2.107 (1.726–2.571)< 0.0011.759 (1.503–2.058)< 0.001
  1. Abbreviation: HBsAg hepatitis B virus surface antigen, ALT anlanine transaminase, NLR indicates neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, APRI alanine transaminase to platelet ratio index, AFP alpha fetoprotein, MVI microscopic vascular invasion, Macro-VTT macroscopic venous tumor thrombus, including portal vein tumor thrombus and hepatic vein tumor thrombus