Table 2 Baseline characteristics of patients with PBT and those without PBT in different HCC stage subset in the matched cohort (n = 576)
Variable | BCLC 0-A (n = 317) | BCLC B-C (n = 259) | ||||
|---|---|---|---|---|---|---|
PBT n = 156) | Non-PBT (n = 161) | P-value | PBT (n = 132) | Non-PBT (n = 127) | P-value | |
Demographic factors | ||||||
 Age, yr | 52.7 ± 12.3 | 53.1 ± 12.4 | 0.787 | 49.2 ± 12.6 | 51.4 ± 13.1 | 0.182 |
Sex, n (%) | ||||||
 Male | 127 (81.4) | 126 (78.3) | 0.487 | 118 (89.4) | 115 (90.6) | 0.758 |
 Female | 29 (18.6) | 35 (21.7) |  | 14 (10.6) | 12 (9.4) |  |
HBsAg, n (%) | ||||||
 Positive | 132 (84.6) | 138 (85.7) | 0.784 | 112 (84.8) | 103 (81.1) | 0.424 |
 Negative | 24 (15.4) | 23 (14.3) |  | 20 (15.2) | 24 (18.9) |  |
Cirrhosis, n (%) | ||||||
 Yes | 144 (73.1) | 121 (75.2) | 0.674 | 101 (76.5) | 93 (73.2) | 0.544 |
 No | 42 (26.9) | 40 (24.8) |  | 31 (23.5) | 34 (26.8) |  |
 Hemoglobin, g/L | 132.0 ± 21.5 | 133.4 ± 19.8 | 0.548 | 136.3 ± 21.1 | 133.4 ± 19.4 | 0.245 |
 Platelet count, ×109 /L | 201.8 ± 93.3 | 180.6 ± 71.3 | 0.023 | 197.8 ± 85.0 | 207.9 ± 73.4 | 0.307 |
 Prothrombin time, s | 12.9 ± 1.6 | 12.9 ± 0.1 | 0.705 | 13.0 ± 1.1 | 13.0 ± 1.1 | 0.894 |
 ALT, U/L, median (range) | 38 (6293) | 34 (71428) | 0.931 | 44 (8, 237) | 38 (12,522) | 0.541 |
ALBI grade, n (%) | ||||||
 Grade 1 | 82 (52.5) | 77 (47.8) | 0.486 | 64 (48.4) | 53 (41.7) | 0.341 |
 Grade 2 | 72 (46.2) | 83 (51.6) |  | 67 (50.8) | 74 (58.3) |  |
 Grade 3 | 2 (1.3) | 1 (0.6) |  | 1 (0.8) | 0 |  |
Inflammatory factors | ||||||
 NLR, median (range) | 2.2 (0.52,13.03) | 2.1 (0.3, 24.9) | 0.904 | 2.3 (0.9, 24.4) | 2.5 (1.1, 15.8) | 0.901 |
 PLR, median (range) | 117.8 (21.4, 405.4) | 107.8 (19.4, 414.0) | 0.379 | 118.4 (19.8, 460.3) | 131.1 (20.6, 314.6) | 0.440 |
 APRI, median (range) | 0.5 (0.1, 5.3) | 0.5 (0.1, 21.1) | 0.621 | 0.6 (0.1, 3.8) | 0.5 (0.1, 5.7) | 0.269 |
Tumor characteristics | ||||||
 AFP, ug/L | ||||||
   ≥ 400 | 64 (41.0) | 60 (37.3) | 0.493 | 61 (46.2) | 70 (55.1) | 0.153 |
   < 400 | 92 (59.0) | 101 (68.9) |  | 71 (53.8) | 57 (44.9) |  |
  Tumor size, cm | 8.4 ± 4.4 | 7.69 ± 3.86 | 0.110 | 9.8 ± 3.5 | 10.1 ± 3.5 | 0.441 |
Tumor number, n (%) | ||||||
 Solitary | 153 (98.1) | 156 (96.7) | 0.502 | 38 (28.8) | 45 (35.4) | 0.524 |
 2 | 3 (1.9) | 5 (3.1) |  | 48 (36.4) | 45 (35.4) |  |
 3 | 0 | 0 |  | 16 (12.1) | 4 (3.2) |  |
 4 | 0 | 0 |  | 30 (22.7) | 33 (26.0) |  |
Tumor capsule, n (%) | ||||||
 Complete | 127 (81.4) | 135 (83.9) | 0.568 | 86 (65.2) | 81 (63.8) | 0.818 |
 Incomplete | 29 (18.6) | 26 (16.1) |  | 46 (34.8) | 46 (36.2) |  |
Differentiation, n (%) | ||||||
 I+ II | 108 (69.2) | 111 (68.9) | 0.956 | 88 (66.7) | 85 (66.9) | 0.964 |
 III, IV | 48 (30.8) | 50 (16.1) |  | 44 (33.3) | 42 (33.1) |  |
MVI, n (%) | ||||||
 Yes | 35 (22.4) | 33 (20.5) | 0.674 | 62 (47.0) | 66 (52.0) | 0.196 |
 No | 121 (77.6) | 128 (79.5) |  | 70 (53.0) | 61 (48.0) |  |
PVTT, n (%) | ||||||
 Yes | 0 | 0 |  | 68 (51.5) | 72 (56.7) | 0.405 |
 No | 156 (100) | 161 (100) |  | 64 (48.5) | 55 (43.3) |  |
HVTT | ||||||
 Yes | 0 | 0 |  | 9 (6.8) | 5 (3.9) | 0.307 |
 No | 156 (100) | 161 (100) |  | 123 (93.2) | 122 (96.1) |  |
Surgical factors | ||||||
 Extent of resection, n (%) | ||||||
  Major | 59 (37.8) | 58 (36.0) | 0.741 | 91 (68.9) | 83 (65.4) | 0.541 |
  Minor | 97 (62.2) | 103 (64.0) |  | 41 (31.1) | 44 (34.6) |  |
Type of resection, n (%) | ||||||
 Anatomical | 55 (35.3) | 53 (32.9) | 0.662 | 68 (51.5) | 69 (54.3) | 0.651 |
 nonanatomical | 101 (64.7) | 108 (67.1) |  | 64 (48.5) | 58 (45.7) |  |
Resection margin, cm | ||||||
  ≤ 1 | 51 (32.7) | 45 (28.0) | 0.358 | 99 (75.0) | 100 (78.7) | 0.476 |
  > 1 | 105 (67.3) | 116 (72.0) |  | 33 (25.0) | 27 (21.3) |  |
Pringle maneuver, n (%) | ||||||
 Yes | 56 (35.9) | 46 (28.6) | 0.163 | 100 (75.7) | 98 (77.2) | 0.790 |
 No | 100 (64.1) | 115 (71.4) |  | 32 (24.3) | 29 (22.7) |  |
Blood loss, ml, median (range)a | 1000 (50, 12,000) | 200 (50,3000) | < 0.001 | 1000 (15,7000) | 300 (50,2500) | < 0.001 |
Clavien-Dindo gradea | ||||||
 I | 3 (1.9) | 3 (1.9) | 0.923 | 1 (0.8) | 4 (3.1) | 0.689 |
 II | 1 (0.6) | 3 (1.9) |  | 1 (0.8) | 2 (1.6) |  |
 III | 12 (7.7) | 12 (7.5) |  | 6 (4.5) | 7 (5.5) |  |
 IV | 2 (1.3) | 1 (0.6) |  | 2 (1.5) | 1 (0.8) |  |