Incidence of subsequent primary cancers and radiation-induced subsequent primary cancers after low dose-rate brachytherapy monotherapy for prostate cancer in long-term follow-up

Table 3 Subsequent primary cancers fulfilling the criteria of an radiation-induced subsequent primary cancer

Age at the time of LDR-BT (y)	In-field SPCs diagnosed ≥ 5 years after LDR-BT	Time to an in-field SPC (y) after LDR-BT	Status at the cut-off date	TTD from the diagnosis of an RISPC due to an RISPC (mo)
60	squamous cell carcinoma of the prostate, grade 2	9.3	death due to the RISPC	7
74	invasive urothelial cancer of the bladder, grade 3, pT1N0M0	9.8	death due to the RISPC	5
57	adenocarcinoma of the rectum, grade 2, pT2N0M0	9.9	alive
72	papillary urothelial neoplasia of the bladder	13.3	alive

LDR-BT Low dose-rate brachytherapy, SPC Subsequent primary cancer, RISPC Radiation induced subsequent primary cancer, TTD Time to death, y years, mo months

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