Table 2 Overall survival of the preoperative NLR, PLR and MLR with other clinicopathological variables
Clinicopathologic Characteristics | Univariate Analysis, HR (95% CI) | P | Multivariate Analysis, HR (95% CI) | P |
|---|---|---|---|---|
Age, y | ||||
 <55 | 1.00 |  | 1.00 |  |
 55–64 | 0.91 (0.62–1.34) | 0.622 | 0.99 (0.66–1.49) | 0.969 |
 65–74 | 2.27 (1.40–3.67) | 0.001 | 2.57 (1.56–4.23) | <0.001 |
  ≥ 75 | 3.69 (1.92–7.11) | <0.001 | 2.86 (1.44–5.68) | 0.003 |
Stage | ||||
 I | 1.00 |  | 1.00 |  |
 II | 2.02 (1.17–3.49) | 0.012 | 1.34 (0.76–2.37) | 0.314 |
 III | 6.89 (4.69–10.12) | <0.001 | 3.26 (2.13–4.98) | <0.001 |
 IV | 11.29 (6.33–20.14) | <0.001 | 2.68 (1.41–5.10) | 0.003 |
Grade | ||||
 1 | 1.00 |  | 1.00 |  |
 2 | 2.43 (1.43–4.12) | 0.001 | 1.85 (1.06–3.23) | 0.030 |
 3 | 8.54 (5.21–13.99) | <0.001 | 3.80 (2.22–6.51) | <0.001 |
BMI, kg/m2 | ||||
 <25 | 1.00 |  | 1.00 |  |
 25–30 | 1.21 (0.80–1.82) | 0.367 | 1.19 (0.78–1.82) | 0.409 |
  ≥ 30 | 0.89 (0.48–1.66) | 0.713 | 1.07 (0.57–2.03) | 0.828 |
Diabetes | ||||
 Absent | 1.00 |  | 1.00 |  |
 Present | 1.04 (0.65–1.68) | 0.854 | 0.94 (0.57–1.54) | 0.794 |
Lymphovascular space invasion | ||||
 Absent | 1.00 |  | 1.00 |  |
 Present | 6.75 (4.19–10.88) | <0.001 | 3.11 (1.86–5.20) | <0.001 |
Histopathological subtype | ||||
 Endometrioid | 1.00 |  | 1.00 |  |
 Stromal sarcoma | 2.34 (0.32–16.80) | 0.399 | 0.34 (0.04–2.83) | 0.321 |
 Clear cell | 2.69 (0.37–19.35) | 0.325 | 0.71 (0.09–5.26) | 0.733 |
 Serous | 6.91 (4.10–11.63) | <0.001 | 1.02 (0.55–1.89) | 0.939 |
 Mixed | 4.87 (2.45–9.69) | <0.001 | 2.76 (1.31–5.79) | 0.007 |
 Carcinosarcoma | 7.76 (4.72–12.75) | <0.001 | 2.80 (1.61–4.87) | <0.001 |
NLR | ||||
 <2.14 | 1.00 |  | 1.00 |  |
  ≥ 2.14 | 3.96 (2.72–5.78) | <0.001 | 2.71 (1.83–4.02) | <0.001 |
PLR | ||||
 <131.82 | 1.00 |  | 1.00 |  |
  ≥ 131.82 | 3.54 (2.47–5.08) | <0.001 | 2.75 (1.90–3.97) | <0.001 |
MLR | ||||
 <0.22 | 1.00 |  | 1.00 |  |
  ≥ 0.22 | 2.12 (1.52–2.97) | <0.001 | 1.72 (1.20–2.45) | 0.003 |
Combined NLR + PLR + MLR | ||||
 NLR low + PLR low + MLR low | 1.00 |  | 1.00 |  |
 NLR low + PLR high + MLR high | 1.02 (1.57–6.59E157) | 0.952 | <0.001 (0.000–5.56E197) | 0.961 |
 NLR low + PLR low + MLR high | 0.47 (0.10–1.83) | 0.252 | 0.40 (0.09–1.74) | 0.225 |
 NLR high + PLR low + MLR low | 2.07 (0.96–4.45) | 0.063 | 1.42 (0.64–3.15) | 0.391 |
 NLR high + PLR low + MLR high | 3.83 (1.86–7.89) | <0.001 | 2.41 (1.13–5.15) | 0.023 |
 NLR low + PLR high + MLR low | 3.92 (2.01–7.62) | <0.001 | 2.59 (1.31–5.11) | 0.006 |
 NLR high + PLR high + MLR low | 3.80 (1.93–7.47) | <0.001 | 2.96 (1.50–5.89) | 0.002 |
 NLR high + PLR high + MLR high | 7.04 (4.22–11.76) | <0.001 | 4.34 (2.54–7.42) | <0.001 |