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Table 3 The value of SCC antigen levels on assessment of rate of positive lymph nodes and survival time of patients with cervical squamous cell carcinoma

From: Clinical value of serum squamous cell carcinoma antigen levels in predicting chemosensitivity, lymph node metastasis, and prognosis in patients with cervical squamous cell carcinoma

Group Factors Cut-off Sen (%) Spe (%) PPV (%) NPV (%) AUC (95%CI) P of AUC
Positive rate of lymph nodes
 Conventional group (n = 39) SCC antigen ≥ 6.75 80.0 (16/20) 100.0 (19/19) 100.0 (16/16) 82.6 (19/23) 0.893 (0.780, 1.000) < 0.001
 NACT group (n = 64) ISCC ≥ 3.90 80.8 (21/26) 47.4 (18/38) 51.2 (21/41) 78.3 (18/23) 0.677 (0.543, 0.810) 0.017
SSCC ≥ 2.10 73.1 (19/26) 71.1 (27/38) 63.3 (19/30) 79.4 (27/34) 0.739 (0.610, 0.869) 0.001
FSCC ≥ 1.45 80.8 (21/26) 50.0 (19/38) 52.5 (21/40) 79.2 (19/24) 0.634 (0.495, 0.773) 0.071
TSCC ≥ 1.55 76.9 (20/26) 57.9 (22/38) 55.6 (20/36) 78.6 (22/28) 0.655 (0.519, 0.791) 0.036
Survival times
 Conventional group (n = 39) SCC ≤ 3.45 80.0 (4/5) 67.6 (23/34) 26.7 (4/15) 95.8 (23/24) 0.656 (0.359, 0.953) 0.266
 NACT group (n = 63) ISCC ≥ 4.55 100.0 (11/11) 57.7 (30/52) 33.3 (11/33) 100.0 (30/30) 0.798 (0.679, 0.917) 0.002
SSCC ≥ 2.70 81.8 (9/11) 71.2 (37/52) 37.5 (9/24) 94.9 (37/39) 0.803 (0.667, 0.940) 0.002
OSCC ≥ 2.75 81.8 (9/11) 80.8 (42/52) 47.4 (9/19) 95.5 (42/44) 0.839 (0.730, 0.948) < 0.001
FSCC ≥ 2.80 81.8 (9/11) 61.5 (32/52) 31.0 (9/29) 94.1 (32/34) 0.738 (0.585, 0.891) 0.014
TSCC ≥ 1.35 90.9 (10/11) 46.2 (24/52) 26.3 (10/38) 96.0 (24/25) 0.677 (0.507, 0.846) 0.067
  1. One patient in the NACT group had a lack of survival time. ISCC The SCC antigen level before the first chemotherapy, SSCC The SCC antigen level after the first chemotherapy, OSCC The SCC antigen level after the second chemotherapy, FSCC The absolute value of the decreased SCC antigen level after the first chemotherapy, TSCC The absolute value of the decreased SCC antigen level after total chemotherapy