Preoperative SCC-Ag as a predictive marker for the use of adjuvant chemotherapy in cervical squamous cell carcinoma with intermediate-risk factors

Table 7 Multivariate Analyses of DFS, LRFS, and DMFS for Patients with high SCC level

Variable	DFS		LRFS		DMFS
Variable	HR (95%CI)	p value	HR (95%CI)	p value	HR (95%CI)	p value
Adjuvant chemotherapy Yes vs no	0.456 (0.217–0.957)	0.038	0.538 (0.207–1.401)	0.204	0.282 (0.111–0.721)	0.008
Tumor size ≥4 cm vs < 4 cm	2.988 (1.278–6.984)	0.012	3.213 (1.426–7.335)	0.007	1.731 (0.701–4.276)	0.234
DSI Yes vs no	2.083 (0.988–4.391)	0.054	2.886 (1.012–8.235)	0.048	1.410 (0.603–3.296)	0.428
LVSI No vs yes	0.645 (0.319–1.302)	0.221	0.610 (0.241–1.541)	0.296	0.658 (0.288–1.501)	0.319

Abbreviations: DFS disease-free survival, LRFS local recurrence-free survival, DMFS distant metastasis-free survival, DSI deep stromal invasion, LVSI lymph-vascular space invasion, SCC squamous cell carcinoma;

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