Table 1 Cumulative incidences of death among patients with ASC
Variables | Nt (%) | Ne (%) | Â | LC-SM (%) | Â | Â | OCSM (%) | Â |
|---|---|---|---|---|---|---|---|---|
3-year (95% CI) | 5-year (95% CI) | P | 3-year (95% CI) | 5-year(95% CI) | P | |||
Total | 2705 | 1897 | 49.6 (47.7–51.5) | 55.8 (53.8–57.8) |  | 8.2 (7.1–9.2) | 11.8 (10.5–13.1) |  |
Age (years) | ||||||||
 median (IQR) | 69 (61–76) | 70 (62–77) |  |  |  |  |  |  |
  < 65 years | 929 (34.3) | 608 (32.1) | 49.2 (45.9–52.4) | 55.0 (51.6–58.3) | 0.275 | 5.1 (3.7–6.5) | 8.0 (6.2–9.9) | < 0.001 |
  ≥ 65 years | 1776 (65.7) | 1289 (67.9) | 49.9 (47.5–52.2) | 56.3 (53.8–58.7) |  | 9.8 (8.4–11.2) | 13.9 (12.2–15.6) |  |
Sex | Â | Â | Â | Â | 0.002 | Â | Â | 0.421 |
 Female | 1268 (46.9) | 858 (45.2) | 45.8 (43.0–48.6) | 52.4 (49.5–55.3) |  | 8.3 (6.8–9.9) | 11.9 (10.0–13.8) |  |
 Male | 1437 (53.1) | 1039 (54.8) | 53.0 (50.4–55.6) | 58.8 (56.1–61.5) |  | 8.0 (6.6–9.5) | 11.8 (10.0–13.6) |  |
Race | Â | Â | Â | Â | 0.008 | Â | Â | 0.027 |
 Black | 262 (9.7) | 195 (10.3) | 56.8 (50.7–63.0) | 62.9 (56.7–69.1) |  | 7.0 (3.9–10.2) | 12.4 (8.0–16.8) |  |
 White | 2248 (83.1) | 1571 (82.8) | 48.4 (46.3–50.5) | 54.4 (52.2–56.6) |  | 8.6 (7.4–9.8) | 12.2 (10.8–13.7) |  |
 Other race | 195 (7.2) | 131 (6.9) | 54.3 (46.9–61.7) | 63.1 (55.6–70.6) |  | 4.3 (1.4–7.3) | 6.0 (2.3–9.7) |  |
Marital status | Â | Â | Â | Â | 0.018 | Â | Â | 0.455 |
 Married | 1590 (58.8) | 1091 (57.5) | 48.1 (45.5–50.6) | 54.2 (51.6–56.8) |  | 7.9 (6.5–9.2) | 11.3 (9.7–13.0) |  |
 Unmarried | 1115 (41.2) | 806 (42.5) | 51.9 (48.9–54.9) | 58.1 (55.1–61.2) |  | 8.6 (6.9–10.3) | 12.6 (10.5–14.7) |  |
Tumour site |  |  |  |  | < 0.001 |  |  | 0.213 |
 Upper lobe | 1651 (61.0) | 1130 (59.6) | 47.8 (45.3–50.3) | 53.7 (51.2–56.3) |  | 8 (6.7–9.4) | 12 (10.3–13.7) |  |
 Middle lobe | 113 (4.2) | 79 (4.2) | 42.4 (33.1–51.7) | 53.8 (43.7–63.8) |  | 11.2 (5.1–17.2) | 18.6 (10.6–26.6) |  |
 Lower lobe | 838 (31.0) | 605 (31.9) | 52.3 (48.8–55.7) | 58.2 (54.7–61.7) |  | 8.5 (6.5–10.4) | 11.4 (9.1–13.7) |  |
 Main bronchus | 58 (2.1) | 53 (2.8) | 82 (71.6–92.5) | 86.8 (76.9–96.7) |  | 5.2 (0–11) | 5.2 (0–11.0) |  |
 Overlapping lesion | 45 (1.7) | 30 (1.6) | 42.8 (28–57.6) | 52.8 (37.5–68.0) |  | 4.6 (0–11) | 7.1 (0–15.0) |  |
Tumour laterality | Â | Â | Â | Â | 0.131 | Â | Â | 0.165 |
 Right | 1564 (57.8) | 1105 (58.2) | 48.7 (46.2–51.2) | 55.2 (52.6–57.8) |  | 8.6 (7.2–10) | 12.9 (11.1–14.7) |  |
 Left | 1135 (42.0) | 787 (41.5) | 50.8 (47.9–53.8) | 56.4 (53.4–59.4) |  | 7.6 (6–9.2) | 10.4 (8.5–12.3) |  |
 Bilateral | 6 (0.2) | 5 (0.3) | 66.7 (22.2–111.2) | 83.3 (43.8–100) |  | 0 (0–0) | 0 (0–0) |  |
Grade |  |  |  |  | < 0.001 |  |  | < 0.001 |
 Grade I | 35 (1.3) | 21 (1.1) | 21.1 (6.8–35.3) | 21.1 (6.8–35.3) |  | 21.5 (7–36) | 25.6 (9.6–41.5) |  |
 Grade II | 857 (31.7) | 529 (27.9) | 38.2 (34.8–41.5) | 45.9 (42.4–49.5) |  | 7.5 (5.7–9.3) | 12.8 (10.4–15.3) |  |
 Grade III | 1751 (64.7) | 1294 (68.2) | 55.4 (53.1–57.8) | 61.1 (58.7–63.5) |  | 8.3 (6.9–9.6) | 11.1 (9.5–12.6) |  |
 Grade IV | 62 (2.3) | 53 (2.8) | 60.1 (47.7–72.6) | 62.1 (49.6–74.6) |  | 8.2 (1.2–15.2) | 12.2 (3.5–20.8) |  |
T stage |  |  |  |  | < 0.001 |  |  | < 0.001 |
 T1 | 736 (27.2) | 402 (21.2) | 26.8 (23.5–30.1) | 32.8 (29.2–36.4) |  | 9.4 (7.2–11.6) | 16.3 (13.3–19.2) |  |
 T2 | 1213 (44.8) | 839 (44.2) | 47.2 (44.4–50.1) | 54.2 (51.3–57.2) |  | 9 (7.4–10.7) | 12.1 (10.2–14.0) |  |
 T3 | 211 (7.8) | 174 (9.2) | 68.9 (62.5–75.3) | 74.6 (68.4–80.9) |  | 6.6 (3.1–10.1) | 9.9 (5.5–14.4) |  |
 T4 | 545 (20.1) | 482 (25.4) | 78.2 (74.6–81.7) | 83.1 (79.7–86.5) |  | 5.2 (3.3–7.1) | 6.1 (4.0–8.2) |  |
N stage |  |  |  |  | < 0.001 |  |  | < 0.001 |
 N0 | 1475 (54.5) | 892 (47.0) | 33.8 (31.4–36.3) | 40.6 (38.0–43.2) |  | 9.6 (8–11.1) | 14.9 (12.9–16.9) |  |
 N1 | 362 (13.4) | 245 (12.9) | 51.5 (46.2–56.7) | 58.6 (53.2–64.0) |  | 5.6 (3.1–8) | 8.3 (5.2–11.4) |  |
 N2 | 711 (26.3) | 617 (32.5) | 73.8 (70.5–77.1) | 79.2 (76.0–82.3) |  | 7 (5.1–8.9) | 8.3 (6.2–10.4) |  |
 N3 | 157 (5.8) | 143 (7.5) | 85.1 (79.2–91.0) | 87.3 (81.5–93.2) |  | 6.6 (2.6–10.5) | 6.6 (2.6–10.5) |  |
M stage |  |  |  |  | < 0.001 |  |  | < 0.001 |
 M0 | 2108 (77.9) | 1344 (70.8) | 39.8 (37.7–42) | 46.9 (44.7–49.2) |  | 8.9 (7.6–10.1) | 13.3 (11.8–14.9) |  |
 M1 | 597 (22.1) | 553 (29.2) | 84.2 (81.2–87.1) | 87.1 (84.2–89.9) |  | 5.8 (3.9–7.7) | 6.5 (4.5–8.6) |  |
AJCC Stage |  |  |  |  | < 0.001 |  |  | < 0.001 |
 I | 1142 (42.2) | 624 (32.9) | 23.9 (21.4–26.4) | 31.1 (28.3–34.0) |  | 11.2 (9.3–13.1) | 17.2 (14.8–19.6) |  |
 II | 332 (12.3) | 213 (11.2) | 47.1 (41.6–52.6) | 52.7 (47.1–58.4) |  | 5.7 (3.1–8.3) | 9.4 (6.0–12.8) |  |
 III | 634 (23.4) | 507 (26.7) | 64.9 (61.1–68.8) | 72.8 (69.1–76.5) |  | 6.3 (4.3–8.2) | 8.4 (6.0–10.7) |  |
 IV | 597 (22.1) | 553 (29.2) | 84.2 (81.2–87.1) | 87.1 (84.2–89.9) |  | 5.8 (3.9–7.7) | 6.5 (4.5–8.6) |  |
Surgery |  |  |  |  | < 0.001 |  |  | < 0.001 |
 No | 886 (32.8) | 806 (42.5) | 82.1 (79.5–84.7) | 85.9 (83.4–88.5) |  | 7.9 (6.1–9.7) | 8.8 (6.8–10.8) |  |
 Yes | 1819 (67.2) | 1091 (57.5) | 34.1 (31.8–36.3) | 41.7 (39.3–44.0) |  | 8.3 (7–9.6) | 13.3 (11.6–15.0) |  |