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Table 1 Cumulative incidences of death among patients with ASC

From: A competing risk nomogram predicting cause-specific mortality in patients with lung adenosquamous carcinoma

Variables Nt (%) Ne (%)   LC-SM (%)    OCSM (%)  
3-year (95% CI) 5-year (95% CI) P 3-year (95% CI) 5-year(95% CI) P
Total 2705 1897 49.6 (47.7–51.5) 55.8 (53.8–57.8)   8.2 (7.1–9.2) 11.8 (10.5–13.1)  
Age (years)
 median (IQR) 69 (61–76) 70 (62–77)       
  < 65 years 929 (34.3) 608 (32.1) 49.2 (45.9–52.4) 55.0 (51.6–58.3) 0.275 5.1 (3.7–6.5) 8.0 (6.2–9.9) < 0.001
  ≥ 65 years 1776 (65.7) 1289 (67.9) 49.9 (47.5–52.2) 56.3 (53.8–58.7)   9.8 (8.4–11.2) 13.9 (12.2–15.6)  
Sex      0.002    0.421
 Female 1268 (46.9) 858 (45.2) 45.8 (43.0–48.6) 52.4 (49.5–55.3)   8.3 (6.8–9.9) 11.9 (10.0–13.8)  
 Male 1437 (53.1) 1039 (54.8) 53.0 (50.4–55.6) 58.8 (56.1–61.5)   8.0 (6.6–9.5) 11.8 (10.0–13.6)  
Race      0.008    0.027
 Black 262 (9.7) 195 (10.3) 56.8 (50.7–63.0) 62.9 (56.7–69.1)   7.0 (3.9–10.2) 12.4 (8.0–16.8)  
 White 2248 (83.1) 1571 (82.8) 48.4 (46.3–50.5) 54.4 (52.2–56.6)   8.6 (7.4–9.8) 12.2 (10.8–13.7)  
 Other race 195 (7.2) 131 (6.9) 54.3 (46.9–61.7) 63.1 (55.6–70.6)   4.3 (1.4–7.3) 6.0 (2.3–9.7)  
Marital status      0.018    0.455
 Married 1590 (58.8) 1091 (57.5) 48.1 (45.5–50.6) 54.2 (51.6–56.8)   7.9 (6.5–9.2) 11.3 (9.7–13.0)  
 Unmarried 1115 (41.2) 806 (42.5) 51.9 (48.9–54.9) 58.1 (55.1–61.2)   8.6 (6.9–10.3) 12.6 (10.5–14.7)  
Tumour site      < 0.001    0.213
 Upper lobe 1651 (61.0) 1130 (59.6) 47.8 (45.3–50.3) 53.7 (51.2–56.3)   8 (6.7–9.4) 12 (10.3–13.7)  
 Middle lobe 113 (4.2) 79 (4.2) 42.4 (33.1–51.7) 53.8 (43.7–63.8)   11.2 (5.1–17.2) 18.6 (10.6–26.6)  
 Lower lobe 838 (31.0) 605 (31.9) 52.3 (48.8–55.7) 58.2 (54.7–61.7)   8.5 (6.5–10.4) 11.4 (9.1–13.7)  
 Main bronchus 58 (2.1) 53 (2.8) 82 (71.6–92.5) 86.8 (76.9–96.7)   5.2 (0–11) 5.2 (0–11.0)  
 Overlapping lesion 45 (1.7) 30 (1.6) 42.8 (28–57.6) 52.8 (37.5–68.0)   4.6 (0–11) 7.1 (0–15.0)  
Tumour laterality      0.131    0.165
 Right 1564 (57.8) 1105 (58.2) 48.7 (46.2–51.2) 55.2 (52.6–57.8)   8.6 (7.2–10) 12.9 (11.1–14.7)  
 Left 1135 (42.0) 787 (41.5) 50.8 (47.9–53.8) 56.4 (53.4–59.4)   7.6 (6–9.2) 10.4 (8.5–12.3)  
 Bilateral 6 (0.2) 5 (0.3) 66.7 (22.2–111.2) 83.3 (43.8–100)   0 (0–0) 0 (0–0)  
Grade      < 0.001    < 0.001
 Grade I 35 (1.3) 21 (1.1) 21.1 (6.8–35.3) 21.1 (6.8–35.3)   21.5 (7–36) 25.6 (9.6–41.5)  
 Grade II 857 (31.7) 529 (27.9) 38.2 (34.8–41.5) 45.9 (42.4–49.5)   7.5 (5.7–9.3) 12.8 (10.4–15.3)  
 Grade III 1751 (64.7) 1294 (68.2) 55.4 (53.1–57.8) 61.1 (58.7–63.5)   8.3 (6.9–9.6) 11.1 (9.5–12.6)  
 Grade IV 62 (2.3) 53 (2.8) 60.1 (47.7–72.6) 62.1 (49.6–74.6)   8.2 (1.2–15.2) 12.2 (3.5–20.8)  
T stage      < 0.001    < 0.001
 T1 736 (27.2) 402 (21.2) 26.8 (23.5–30.1) 32.8 (29.2–36.4)   9.4 (7.2–11.6) 16.3 (13.3–19.2)  
 T2 1213 (44.8) 839 (44.2) 47.2 (44.4–50.1) 54.2 (51.3–57.2)   9 (7.4–10.7) 12.1 (10.2–14.0)  
 T3 211 (7.8) 174 (9.2) 68.9 (62.5–75.3) 74.6 (68.4–80.9)   6.6 (3.1–10.1) 9.9 (5.5–14.4)  
 T4 545 (20.1) 482 (25.4) 78.2 (74.6–81.7) 83.1 (79.7–86.5)   5.2 (3.3–7.1) 6.1 (4.0–8.2)  
N stage      < 0.001    < 0.001
 N0 1475 (54.5) 892 (47.0) 33.8 (31.4–36.3) 40.6 (38.0–43.2)   9.6 (8–11.1) 14.9 (12.9–16.9)  
 N1 362 (13.4) 245 (12.9) 51.5 (46.2–56.7) 58.6 (53.2–64.0)   5.6 (3.1–8) 8.3 (5.2–11.4)  
 N2 711 (26.3) 617 (32.5) 73.8 (70.5–77.1) 79.2 (76.0–82.3)   7 (5.1–8.9) 8.3 (6.2–10.4)  
 N3 157 (5.8) 143 (7.5) 85.1 (79.2–91.0) 87.3 (81.5–93.2)   6.6 (2.6–10.5) 6.6 (2.6–10.5)  
M stage      < 0.001    < 0.001
 M0 2108 (77.9) 1344 (70.8) 39.8 (37.7–42) 46.9 (44.7–49.2)   8.9 (7.6–10.1) 13.3 (11.8–14.9)  
 M1 597 (22.1) 553 (29.2) 84.2 (81.2–87.1) 87.1 (84.2–89.9)   5.8 (3.9–7.7) 6.5 (4.5–8.6)  
AJCC Stage      < 0.001    < 0.001
 I 1142 (42.2) 624 (32.9) 23.9 (21.4–26.4) 31.1 (28.3–34.0)   11.2 (9.3–13.1) 17.2 (14.8–19.6)  
 II 332 (12.3) 213 (11.2) 47.1 (41.6–52.6) 52.7 (47.1–58.4)   5.7 (3.1–8.3) 9.4 (6.0–12.8)  
 III 634 (23.4) 507 (26.7) 64.9 (61.1–68.8) 72.8 (69.1–76.5)   6.3 (4.3–8.2) 8.4 (6.0–10.7)  
 IV 597 (22.1) 553 (29.2) 84.2 (81.2–87.1) 87.1 (84.2–89.9)   5.8 (3.9–7.7) 6.5 (4.5–8.6)  
Surgery      < 0.001    < 0.001
 No 886 (32.8) 806 (42.5) 82.1 (79.5–84.7) 85.9 (83.4–88.5)   7.9 (6.1–9.7) 8.8 (6.8–10.8)  
 Yes 1819 (67.2) 1091 (57.5) 34.1 (31.8–36.3) 41.7 (39.3–44.0)   8.3 (7–9.6) 13.3 (11.6–15.0)  
  1. Abbreviations: Nt total number, Ne number of death events, ASC adenosquamous carcinoma, CI confidence interval, LC-SM lung cancer-specific mortality, OCSM other cause-specific morality, AJCC American Joint Committee on Cancer, IQR interquartile range