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Table 2 Cumulative cancer risks (%) by age

From: Cancer risks in Lynch syndrome, Lynch-like syndrome, and familial colorectal cancer type X: a prospective cohort study

 

LS

Cancer type

Age (years)

FCCX

LLS

LS

MLH1

MSH2

MSH6

Any

40

0.0 (−)

12.5 (4.2–34.1)

12.2 (6.4–22.5)

14.0 (5.5–33.1)

13.8 (5.7–31.4)

0.0 (−)

50

10.0 (1.5–52.7)

20.5 (9.7–40.4)

25.6 (17.5–36.4)

24.1 (12.8–42.6)

31.6 (19.5–48.5)

7.7 (1.1–43.4)

60

10.0 (1.5–52.7)

27.3 (14.5–47.8)

49.0 (37.5–61.9)

44.0 (26.6–66.3)

60.3 (44.0–77.1)

20.9 (5.3–63.3)

70

25.0 (6.6–70.2)

27.3 (14.5–47.8)

63.7 (48.5–78.8)

52.0 (31.9–75.3)

72.2 (53.2–88.4)

36.7 (12.7–78.6)

Colorectal

40

0.0 (−)

12.4 (4.2–33.8)

8.4 (3.7–18.3)

10.0 (3.3–27.9)

9.5 (2.9–28.3)

0.0 (−)

50

0.0 (−)

17.4 (7.5–37.4)

11.8 (6.3–21.5)

10.0 (3.3–27.9)

16.3 (7.7–32.7)

0.0 (−)

60

0.0 (−)

21.0 (9.9–41.3)

25.4 (16.8–37.2)

23.4 (10.8–46.6)

33.7 (21.0–51.1)

0.0 (−)

70

0.0 (−)

21.0 (9.9–41.3)

40.9 (28.3–56.4)

30.4 (14.8–55.8)

49.1 (32.9–68.1)

14.3 (2.1–66.6)

Stomach

40

0.0 (−)

0.0 (−)

0.0 (−)

0.0 (−)

0.0 (−)

0.0 (−)

50

0.0 (−)

0.0 (−)

0.0 (−)

0.0 (−)

0.0 (−)

0.0 (−)

60

0.0 (−)

2.4 (0.6–9.9)

1.7 (0.6–4.6)

0.9 (0.1–6.4)

2.4 (0.8–7.4)

0.0 (−)

70

0.0 (−)

4.6 (1.4–14.5)

2.9 (1.3–6.5)

2.5 (0.6–9.9)

3.6 (1.3–9.5)

0.0 (−)

Small bowel

40

0.0 (−)

0.0 (−)

0.6 (0.1–4.1)

1.4 (0.2–9.8)

0.0 (−)

0.0 (−)

50

0.0 (−)

0.6 (0.1–4.4)

1.8 (0.7–4.8)

1.4 (0.2–9.8)

2.5 (0.8–7.7)

0.0 (−)

60

0.0 (−)

0.6 (0.1–4.4)

5.9 (3.5–10.1)

5.0 (1.9–12.8)

7.6 (4.0–14.2)

0.0 (−)

70

0.0 (−)

0.6 (0.1–4.4)

11.7 (7.6–17.6)

11.5 (5.8–22.0)

13.9 (8.0–23.4)

0.0 (−)

Urothelial

40

0.0 (−)

0.0 (−)

0.0 (−)

0.0 (−)

0.0 (−)

0.0 (−)

50

0.0 (−)

0.0 (−)

2.7 (1.3–5.6)

0.9 (0.1–6.1)

4.7 (2.1–10.3)

0.0 (−)

60

0.0 (−)

1.5 (0.4–5.9)

6.5 (4.0–10.4)

5.7 (2.4–13.3)

8.4 (4.7–14.7)

0.0 (−)

70

0.0 (−)

5.7 (2.0–16.0)

12.5 (8.3–18.5)

11.3 (5.6–22.0)

16.3 (9.9–26.2)

0.0 (−)

Female breast

40

0.0 (−)

0.0 (−)

0.0 (−)

0.0 (−)

0.0 (−)

0.0 (−)

50

0.0 (−)

2.9 (0.7–11.4)

3.4 (1.3–8.7)

2.0 (0.3–13.6)

1.6 (0.2–10.6)

12.0 (3.1–40.6)

60

5.9 (0.9–35.0)

2.9 (0.7–11.4)

7.9 (4.2–14.7)

7.3 (2.4–21.2)

6.8 (2.6–17.1)

12.0 (3.1–40.6)

70

5.9 (0.9–35.0)

2.9 (0.7–11.4)

11.9 (6.8–20.3)

7.3 (2.4–21.2)

12.2 (5.5–25.8)

20.8 (7.0–53.0)

Ovarian

40

0.0 (−)

0.0 (−)

1.0 (0.1–7.1)

0.0 (−)

2.4 (0.3–16.1)

0.0 (−)

50

0.0 (−)

0.0 (−)

2.9 (0.9–8.7)

0.0 (−)

6.8 (2.2–19.6)

0.0 (−)

60

0.0 (−)

0.0 (−)

4.9 (1.7–13.3)

0.0 (−)

10.7 (4.0–26.9)

0.0 (−)

70

0.0 (−)

0.0 (−)

6.4 (2.6–15.5)

0.0 (−)

14.0 (5.9–31.2)

0.0 (−)

Endometrial

40

0.0 (−)

0.0 (−)

1.4 (0.2–9.3)

0.0 (−)

3.1 (0.4–20.2)

0.0 (−)

50

0.0 (−)

4.3 (1.4–12.8)

15.3 (9.1–25.0)

14.5 (6.8–29.6)

16.8 (7.9–33.8)

10.0 (1.5–52.7)

60

0.0 (−)

7.7 (3.2–17.6)

28.8 (19.1–41.9)

19.2 (9.2–37.5)

40.1 (24.5–60.7)

10.0 (1.5–52.7)

70

0.0 (−)

7.7 (3.2–17.6)

36.1 (23.4–52.7)

35.4 (13.8–72.2)

44.1 (27.8–64.5)

10.0 (1.5–52.7)

  1. Numbers in brackets are 95% confidence intervals