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Table 5 Prognostic factors of 5-year overall survival of colorectal cancer in univariate analysis

From: Association of DNA repair gene variants with colorectal cancer: risk, toxicity, and survival

  Total (n = 593) Events (n = 268) Odds ratio (95% confidence interval) p
Age, mean (±SD) yrs 69.4 (± 12.2) 72.4 (± 12.3) 1.03 (1.0–1.1) < 0.0001
Gender, n (%)
 Male 337 (56.8) 157 (58.6)   
 Female 256 (43.2) 111 (41.4) 0.9 (0.6–1.2) 0.4
Tumor location, n (%)
 Rectum 249 (42.3) 116 (43.8)   
 Left-sided colon 132 (22.4) 53 (20.0) 0.8 (0.5–1.2) 0.2
 Right-sided colon 208 (35.3) 96 (36.2) 1.0 (0.7–1.4) 0.9
Tumor differentiation, n (%)
 Well & moderate 445 (76.3) 183 (69.8)   
 Poor 138 (23.7) 79 (30.2) 1.9 (1.3–2.9) 0.001
Stage, n (%)
 I & II 264 (44.8) 78 (29.1)   
 III 232 (39.3) 105 (39.2) 1.9 (1.4–2.8) 0.0002
 IV 94 (15.9) 85 (31.7) 22.5 (10.8–47.3) < 0.0001
Lymph node positive, n (%)
 No 268 (45.2) 83 (31.0)   
 Yes 325 (54.8) 185 (69.0) 2.9 (2.1–4.1) < 0.0001
Lymph node count, n (%)
  < 12 183 (30.9) 99 (36.9)   
  ≥ 12 410 (69.1) 169 (63.1) 0.6 (0.4–0.8) 0.001
Radical operation, n (%)
 No 81 (13.8) 77 (29.3)   
 Yes 506 (86.2) 186 (70.7) 0.03 (0.01–0.1) < 0.001
Year of surgery, n (%)
 1990–2000 140 (23.6) 80 (29.8)   
 2001–2006 453 (76.4) 188 (70.2) 0.5 (0.4–0.8) 0.001
XRCC1-rs25487, n (%)
 G/G 250 (42.6) 113 (43.1)   
 G/A 269 (45.8) 117 (44.7)   
 A/A 68 (11.6) 32 (12.2) 1.0 (0.7–1.4) 0.9
ERCC1-rs11615, n (%)
 T/T 236 (40.9) 105 (40.9)   
 C/T 263 (45.6) 111 (43.1)   
 C/C 78 (13.5) 41 (16.0) 1.1 (0.7–1.4) 0.9
ERCC2-rs238406, n (%)
 C/C 176 (30.9) 73 (29.0)   
 C/A 281 (49.4) 130 (51.6)   
 A/A 112 (19.7) 49 (19.4) 1.1 (0.6–1.2) 0.7
ERCC2-rs13181, n (%)
 A/A 219 (37.9) 99 (39.0)   
 A/C 283 (49.0) 124 (48.8)   
 C/C 76 (13.1) 31 (12.2) 1.1 (0.8–1.5) 0.7