Table 5 Prognostic factors of 5-year overall survival of colorectal cancer in univariate analysis
From: Association of DNA repair gene variants with colorectal cancer: risk, toxicity, and survival
|  | Total (n = 593) | Events (n = 268) | Odds ratio (95% confidence interval) | p |
|---|---|---|---|---|
Age, mean (±SD) yrs | 69.4 (± 12.2) | 72.4 (± 12.3) | 1.03 (1.0–1.1) | < 0.0001 |
Gender, n (%) | ||||
 Male | 337 (56.8) | 157 (58.6) |  |  |
 Female | 256 (43.2) | 111 (41.4) | 0.9 (0.6–1.2) | 0.4 |
Tumor location, n (%) | ||||
 Rectum | 249 (42.3) | 116 (43.8) |  |  |
 Left-sided colon | 132 (22.4) | 53 (20.0) | 0.8 (0.5–1.2) | 0.2 |
 Right-sided colon | 208 (35.3) | 96 (36.2) | 1.0 (0.7–1.4) | 0.9 |
Tumor differentiation, n (%) | ||||
 Well & moderate | 445 (76.3) | 183 (69.8) |  |  |
 Poor | 138 (23.7) | 79 (30.2) | 1.9 (1.3–2.9) | 0.001 |
Stage, n (%) | ||||
 I & II | 264 (44.8) | 78 (29.1) |  |  |
 III | 232 (39.3) | 105 (39.2) | 1.9 (1.4–2.8) | 0.0002 |
 IV | 94 (15.9) | 85 (31.7) | 22.5 (10.8–47.3) | < 0.0001 |
Lymph node positive, n (%) | ||||
 No | 268 (45.2) | 83 (31.0) |  |  |
 Yes | 325 (54.8) | 185 (69.0) | 2.9 (2.1–4.1) | < 0.0001 |
Lymph node count, n (%) | ||||
  < 12 | 183 (30.9) | 99 (36.9) |  |  |
  ≥ 12 | 410 (69.1) | 169 (63.1) | 0.6 (0.4–0.8) | 0.001 |
Radical operation, n (%) | ||||
 No | 81 (13.8) | 77 (29.3) |  |  |
 Yes | 506 (86.2) | 186 (70.7) | 0.03 (0.01–0.1) | < 0.001 |
Year of surgery, n (%) | ||||
 1990–2000 | 140 (23.6) | 80 (29.8) |  |  |
 2001–2006 | 453 (76.4) | 188 (70.2) | 0.5 (0.4–0.8) | 0.001 |
XRCC1-rs25487, n (%) | ||||
 G/G | 250 (42.6) | 113 (43.1) |  |  |
 G/A | 269 (45.8) | 117 (44.7) |  |  |
 A/A | 68 (11.6) | 32 (12.2) | 1.0 (0.7–1.4) | 0.9 |
ERCC1-rs11615, n (%) | ||||
 T/T | 236 (40.9) | 105 (40.9) |  |  |
 C/T | 263 (45.6) | 111 (43.1) |  |  |
 C/C | 78 (13.5) | 41 (16.0) | 1.1 (0.7–1.4) | 0.9 |
ERCC2-rs238406, n (%) | ||||
 C/C | 176 (30.9) | 73 (29.0) |  |  |
 C/A | 281 (49.4) | 130 (51.6) |  |  |
 A/A | 112 (19.7) | 49 (19.4) | 1.1 (0.6–1.2) | 0.7 |
ERCC2-rs13181, n (%) | ||||
 A/A | 219 (37.9) | 99 (39.0) |  |  |
 A/C | 283 (49.0) | 124 (48.8) |  |  |
 C/C | 76 (13.1) | 31 (12.2) | 1.1 (0.8–1.5) | 0.7 |