Table 4 Univariate and multivariate Cox analyses of clinical features for cancer-related survival rates
From: Clinical characteristics and prognostic factors of Hurthle cell carcinoma: a population based study
Features | Univariate | Multivariate | ||
|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |
Gender | ||||
Male | 1 | 1 | ||
Female | 0.415 (0.278–0.619) | < 0.001 | 0.614 (0.409–0.924) | 0.019 |
Age (year) | ||||
< 45 | 1 | 1 | ||
≥ 45 | 6.354 (2.582–15.635) | < 0.001 | 4.204 (1.695–10.432) | 0.002 |
Race | ||||
White | 1 | – | – | |
Black | 0.960 (0.465–1.984) | 0.913 | – | – |
Other | 0.646 (0.237–1.761) | 0.393 | – | – |
SEER stage | ||||
Local | 1 | 1 | ||
Regional | 8.454 (4.823–14.817) | < 0.001 | 8.015 (4.555–14.101) | < 0.001 |
Distant | 61.625 (3.772–31.568) | < 0.001 | 46.219 (27.108–78.804) | < 0.001 |
Tumor multifocality | ||||
No | 1 | – | – | |
Yes | 1.334 (0.808–2.202) | 0.260 | – | – |
Tumor extension | ||||
Intrathyroidal | 1 | – | – | |
Extrathyroidal | 12.342 (8.062–18.892) | < 0.001 | – | – |
Lymph node examination | ||||
Not examined | 1 | – | – | |
Negative | 1.060 (0.646–1.741) | 0.817 | – | – |
Positive | 6.029 (3.494–10.403) | < 0.001 | – | – |
T-stage | ||||
T1 | 1 | – | – | |
T2 | 0.701 (0.226–2.173) | 0.538 | – | – |
T3 | 4.866 (2.060–11.496) | < 0.001 | – | – |
T4 | 42.305 (17.874–100.132) | < 0.001 | – | – |
N-stage | ||||
N0 | 1 | – | – | |
N1 | 8.863 (5.561–14.124) | < 0.001 | – | – |
M-stage | ||||
M0 | 1 | – | – | |
M1 | 32.934 (21.214–51.129) | < 0.001 | – | – |
Surgery | ||||
No | 1 | 1 | ||
Total thyroidectomy | 0.085 (0.044–0.166) | < 0.001 | 0.335 (0.152–0.741) | 0.007 |
Partial thyroidectomy | 0.046 (0.019–0.114) | < 0.001 | 0.266 (0.096–0.742) | 0.011 |
Radiotherapy | ||||
No | 1 | – | – | |
Yes | 0.606 (0.405–0.905) | 0.014 | – | – |