BMC Cancer

Table 4 Survival by mRNA expression for 9 probes correlated with miRs in ESCC (from Supplementary Table S6)^a,b,c

From: Integrated analysis of genome-wide miRNAs and targeted gene expression in esophageal squamous cell carcinoma (ESCC) and relation to prognosis

No.	Gene/Probe	Quartile	HR	95% CI	P-value	P-trend	Log-Rank P-value
1	NF1/204323_x_at	1	1.00	(Ref)
		2	0.93	0.45–1.93	0.8504
		3	0.46	0.19–1.08	0.0748
		4	*0.30*	*0.13–0.71*	*0.0062*
						*0.0037*	0.0805
2	ASXL1/212237_at	1	1.00	(Ref)
		2	0.90	0.44–1.83	0.7743
		3	0.42	0.18–0.95	0.0371
		4	0.46	0.20–1.06	0.0690
						*0.0094*	0.1116
3	HSPA4/208814_at	1	1.00	(Ref)
		2	*2.40*	*1.03–5.61*	*0.0433*
		3	1.94	0.77–4.91	0.1610
		4	*2.84*	*1.29–6.29*	*0.0099*
						*0.0162*	*0.0139*
4	TGOLN2/212043_at	1	1.00	(Ref)
		2	0.86	0.40–1.86	0.7014
		3	0.57	0.26–1.26	0.1664
		4	*0.35*	*0.14–0.86*	*0.0221*
						*0.0223*	0.2394
5	BAIAP2/207832_at	1	1.00	(Ref)
		2	0.69	0.36–1.34	0.2766
		3	0.61	0.31–1.21	0.1588
		4	0.51	0.22–1.15	0.1043
						*0.0245*	0.0823
6	EZH2/203358_s_at	1	1.00	(Ref)
		2	1.36	0.61–3.01	0.4540
		3	*3.55*	*1.55–8.12*	*0.0027*
		4	*2.27*	*1.01–5.11*	*0.0468*
						*0.0247*	*0.0100*
7	CHAF1A/214426_x_at	1	1.00	(Ref)
		2	*2.30*	*1.00–5.30*	*0.0499*
		3	*2.65*	*1.18–5.92*	*0.0177*
		4	*2.56*	*1.17–5.61*	*0.0190*
						*0.0253*	0.0652
8	TGOLN2/212040_at	1	1.00	(Ref)
		2	1.24	0.62–2.50	0.5435
		3	0.55	0.25–1.25	0.1555
		4	*0.35*	*0.13–0.95*	*0.0393*
						*0.0258*	0.2537
9	SUPT7L/201836_s_at	1	1.00	(Ref)
		2	1.09	0.47–2.52	0.8355
		3	0.71	0.34–1.51	0.3746
		4	0.42	0.17–1.01	0.0535
						*0.0329*	0.4634

^amRNA expression modeled as tumor/normal mRNA expression fold change by quartile of expression
^bGenes/probes shown in ascending order by P-trend value
^cModels adjusted for age, gender, metastasis, stage

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