Table 5 Uni- and multi-variable analysis for predictors of disease specific survival of 49 patients with resection
Factors | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
No. of patients | 5-year survival rate (%) | Median survival time (month) | p value | Hazard ratio (95% CI) | p value | |
Preoperative CA19–9 | ||||||
  < 25 U/mL | 14 | 59.1 | – | 0.355 | ||
 25 U/mL ≦ | 35 | 38.6 | 49.4 | |||
Preoperative CEA | ||||||
  < 8.5 ng/mL | 42 | 51.6 | – | < 0.001 | 10.516 (2.213–49.971) | 0.003 |
 8.5 ng/mL ≦ | 7 | 0 | 21.2 | |||
Neoadjuvant therapy | ||||||
 not done | 22 | 61.1 | – | 0.561 | ||
 done | 27 | 39.2 | 52.4 | |||
Adjuvant therapy | ||||||
 not done | 16 | 53.0 | – | 0.897 | ||
 done | 33 | 45.7 | 57.0 | |||
Combined vascular resection and reconstruction | ||||||
 not done | 29 | 31.2 | 52.4 | 0.981 | ||
 done | 20 | 54.0 | – | |||
Histological differentiation | ||||||
 G1/G2 | 45 | 46.7 | 57.0 | 0.001 | 7.452 (0.904–61.403) | 0.062 |
 G3 | 3 | 0 | 19.1 | |||
pT factor | ||||||
 ≦pT3 | 37 | 56.1 | – | 0.001 | 7.452 (2.348–23.713) | 0.001 |
 pT4≦ | 12 | 13.3 | 31.3 | |||
Lymph node metastasis | ||||||
 Negative | 26 | 41.3 | 57.0 | 0.389 | ||
 Positive | 23 | 52.7 | – | |||
Intrahepatic metastasis | ||||||
 Absent | 46 | 45.4 | 57.0 | 0.033 | 0.693 (0.053–9.005) | 0.779 |
 Present | 3 | 0 | – | |||
Curative resection | ||||||
 R0 | 32 | 61.5 | – | 0.037 | 2.283 (0.739–7.058) | 0.152 |
 R1,2 | 17 | 15.1 | 35.7 | |||