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Table 5 Uni- and multi-variable analysis for predictors of disease specific survival of 49 patients with resection

From: Neoadjuvant chemotherapy followed by curative-intent surgery for perihilar cholangiocarcinoma based on its anatomical resectability classification and lymph node status

FactorsUnivariate analysisMultivariate analysis
No. of patients5-year survival rate (%)Median survival time (month)p valueHazard ratio
(95% CI)
p value
Preoperative CA19–9
  < 25 U/mL1459.10.355  
 25 U/mL 3538.649.4   
Preoperative CEA
  < 8.5 ng/mL4251.6< 0.00110.516 (2.213–49.971)0.003
 8.5 ng/mL 7021.2   
Neoadjuvant therapy
 not done2261.10.561  
 done2739.252.4   
Adjuvant therapy
 not done1653.00.897  
 done3345.757.0   
Combined vascular resection and reconstruction
 not done2931.252.40.981  
 done2054.0   
Histological differentiation
 G1/G24546.757.00.0017.452 (0.904–61.403)0.062
 G33019.1   
pT factor
pT33756.10.0017.452 (2.348–23.713)0.001
 pT41213.331.3   
Lymph node metastasis
 Negative2641.357.00.389  
 Positive2352.7   
Intrahepatic metastasis
 Absent4645.457.00.0330.693 (0.053–9.005)0.779
 Present30   
Curative resection
 R03261.50.0372.283 (0.739–7.058)0.152
 R1,21715.135.7   
  1. CEA carcinoembryonic antigen, CA19–9 carbohydrate antigen 19–9, R0 complete resection,R1 microscopic residual tumor resection, R2 macroscopic residual tumor resection or distant metastasis (intrahepatic metastasis)