Table 5 QoL assessment (EORTC QLQ C30 and EORTC QLQ BR 23) by therapy arm and assessment time (Mean scores and standard errors)

 Physical Functioning

81.6 (18.7)

69.2 (4.8)

72.8 (4.5)

71.1 (4.8)

75.4 (4.7)

70.1 (4.8)

73.1 (4.7)

65.7 (6.1)

70.1 (5.8)

62.4 (5.9)

70.1 (5.4)

0.4585

0.3822

 Role Functioning

67.4 (31.1)

65.5 (6.3)

69.2 (5.7)

62.3 (6.4)

65.9 (6.4)

65.8 (6.0)

67.9 (5.9)

58.7 (7.8)

69.7 (7.3)

56.4 (8.8)

68.8 (7.9)

0.3676

0.8800

 Emotional Functioning

65.9 (24.6)

58.1 (4.3)

62.3 (4.1)

62.5 (5.0)

71.4 (5.0)

68.2 (4.5)

73.6 (4.4)

65.2 (5.5)

69.6 (5.2)

69.5 (6.3)

70.6 (5.4)

0.4128

0.0127

 Cognitive Functioning

80.5 (23.2)

89.3 (2.9)

91.6 (2.8)

79.5 (4.1)

83.5 (4.1)

82.0 (4.3)

82.5 (4.3)

78.6 (5.1)

81.5 (4.9)

74.3 (5.2)

83.3 (4.5)

0.4537

0.0058

 Social Functioning

74.2 (28.4)

65.9 (5.6)

76.1 (5.3)

68.6 (5.7)

78.6 (5.8)

76.9 (5.7)

78.2 (5.6)

70.9 (7.4)

72.1 (6.7)

74.3 (6.2)

77.2 (5.3)

0.5507

0.3784

 Global health status/QoL

60.2 (25.5)

47.8 (4.3)

61.6 (4.2)

61.4 (4.5)

68.7 (4.5)

66.0 (4.2)

69.7 (4.2)

63.5 (6.3)

68.7 (5.8)

61.4 (5.9)

71.2 (4.9)

0.2194

0.0032

 Fatigue

36.3 (27.0)

39.3 (5.1)

34.0 (4.7)

43.2 (5.7)

35.2 (5.6)

41.8 (5.6)

37.4 (5.4)

40.8 (6.4)

32.0 (5.9)

47.5 (5.7)

31.2 (5.1)

0.1717

0.6495

 Nausea/Vomiting

10.3 (19.7)

10.5 (2.9)

5.6 (2.7)

9.3 (2.6)

4.9 (2.6)

11.9 (3.7)

6.9 (3.7)

8.0 (3.4)

6.0 (3.1)

18.8 (6.0)

9.4 (5.4)

0.1930

0.2564

 Pain

30.9 (29.6)

37.9 (6.2)

32.2 (5.7)

30.9 (5.5)

22.7 (5.5)

25.7 (5.1)

24.1 (5.1)

28.6 (6.4)

28.3 (6.0)

32.4 (6.6)

26.2 (6.0)

0.5478

0.2441

 Dyspnoea

20.4 (28.2)

15.7 (4.6)

19.1 (4.3)

22.6 (5.3)

24.5 (5.2)

21.9 (5.8)

28.3 (5.7)

34.9 (8.8)

36.7 (8.2)

37.1 (6.9)

26.5 (6.4)

0.9850

0.0257

 Insomnia

33.1 (32.6)

39.5 (5.6)

35.4 (5.3)

36.9 (5.7)

22.1 (5.7)

32.8 (6.1)

30.5 (6.0)

24.5 (7.0)

37.1 (6.5)

32.0 (7.1)

31.0 (6.3)

0.8455

0.5016

 Appetite loss

21.7 (31.0)

23.3 (5.7)

20.9 (5.2)

22.8 (5.7)

11.7 (5.7)

20.2 (5.2)

14.9 (5.2)

17.3 (5.0)

11.6 (4.5)

23.3 (5.7)

13.1 (5.0)

0.1297

0.5374

 Constipation

19.2 (28.8)

18.9 (5.1)

21.0 (4.9)

25.3 (6.4)

19.9 (6.4)

19.4 (5.5)

21.9 (5.5)

11.3 (6.3)

21.3 (5.9)

18.3 (7.9)

22.6 (6.8)

0.6710

0.5871

 Diarrhoea

5.8 (15.2)

3.9 (3.2)

8.7 (3.1)

10.1 (4.8)

9.0 (4.6)

12.9 (3.6)

4.9 (3.5)

13.8 (4.9)

6.7 (4.7)

7.7 (3.3)

4.4 (3.1)

0.2765

0.2127

 Financial Problems

16.3 (4.4)

9.4 (4.1)

27.4 (5.2)

11.2 (5.1)

27.1 (5.9)

18.8 (5.7)

27.3 (6.5)

23.8 (6.2)

19.5 (5.3)

18.3 (4.9)

0.2845

0.0308

 Body image

81.9 (22.6)

83.2 (3.7)

83.2 (3.5)

71.2 (5.4)

78.1 (5.2)

82.9 (4.2)

81.7 (4.0)

78.5 (5.3)

79.5 (4.8)

73.1 (5.6)

74.9 (5.1)

0.7139

0.0178

 Sexual functioning

19.2 (23.2)

12.6 (4.4)

18.5 (4.2)

17.4 (4.5)

17.2 (4.4)

15.6 (5.7)

24.3 (5.4)

18.6 (6.2)

22.5 (5.2)

12.6 (6.0)

24.6 (5.2)

0.3300

0.7514

 Future perspective

47.6 (34.1)

21.4 (5.4)

45.0 (5.0)

33.8 (6.1)

42.5 (5.9)

46.0 (6.5)

49.9 (6.2)

31.0 (7.7)

49.5 (6.9)

52.2 (8.2)

54.8 (7.5)

0.2336

0.0093

 Systematic therapy

15.8 (14.3)

18.4 (3.0)

17.0 (2.7)

31.9 (4.1)

27.9 (4.1)

21.4 (3.0)

17.8 (2.9)

25.1 (4.0)

23.9 (3.7)

23.3 (3.5)

21.9 (3.2)

0.5214

<.0001

 Breast symptoms

17.6 (16.7)

26.7 (3.4)

14.1 (3.2)

20.1 (3.0)

8.8 (3.0)

13.7 (2.6)

9.9 (2.6)

10.4 (3.9)

12.0 (3.6)

7.3 (3.9)

10.6 (3.6)

0.4559

0.0056

 Arm symptoms

21.0 (21.1)

18.1 (3.2)

14.2 (3.0)

28.3 (4.3)

14.5 (4.2)

23.7 (4.0)

15.1 (3.8)

29.1 (5.1)

19.2 (4.8)

18.3 (4.7)

15.8 (4.4)

0.0949

0.0575

 Hair loss

5.3 (19.3)

2.6 (2.6)

4.6 (2.4)

32.5 (7.1)

27.6 (7.1)

16.3 (4.8)

-0.4 (4.3)

18.3 (5.5)

8.0 (5.0)

9.9 (7.6)

13.0 (6.8)

0.2203

<.0001