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Table 1 CD73 expression levels and clinical and pathological findings of 64 patients with rectal cancer treated with neoadjuvant radiation therapy

From: CD73 blockade enhances the local and abscopal effects of radiotherapy in a murine rectal cancer model

VariableTumor cells (64)Stroma (64)
Low (38)High (22)Unknown (4)p-valueLow (27)High (37)p-value
Age63 (36–78)59 (42–79)66 (63–68)0.1361 (36–74)62 (44–79)0.8
Gender
M291630.7719290.56
F961 88 
Location
Rab21 0.69210.48
Rb3621  2536 
Histology
Differentiated3220 0.722310.46
Undifferentiated62  26 
Lymphatic invasion
Absent2411 0.4217220.8
Present1411  1015 
Venous invasion
Absent139 0.7810160.8
Present2513  1721 
Tumor Stage
t0/t14040.48530.35
t295  77 
t32314  1225 
t423  32 
N stage
n02315 0.5917250.79
n1<157  1012 
Pathological response
grade 0/12517 0.2918240.63
grade 21351 712 
grade 3003 21 
Combined Chemotherapy
Not given3400.31430.2
Given35184 2334 
Adjuvant chemotherapy
Given165 0.139120.99
Not Given22174 1825 
Recurrence
Present1111 0.166160.11
Absent27114 2121 
  1. CD73 expression in tumor cells cannot be appropriately evaluated in 1 patient with a grade 2 response due to few remaining tumor cells as well as in 3 patients with grade 3 responses (pathological complete response). Statistical significance of the differences was evaluated by student-t-test, the Mann-Whitney test, the χ2-test and Fisher’s exact test
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