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Table 1 CD73 expression levels and clinical and pathological findings of 64 patients with rectal cancer treated with neoadjuvant radiation therapy

From: CD73 blockade enhances the local and abscopal effects of radiotherapy in a murine rectal cancer model

Variable

Tumor cells (64)

Stroma (64)

Low (38)

High (22)

Unknown (4)

p-value

Low (27)

High (37)

p-value

Age

63 (36–78)

59 (42–79)

66 (63–68)

0.13

61 (36–74)

62 (44–79)

0.8

Gender

M

29

16

3

0.77

19

29

0.56

F

9

6

1

 

8

8

 

Location

Rab

2

1

 

0.69

2

1

0.48

Rb

36

21

  

25

36

 

Histology

Differentiated

32

20

 

0.7

22

31

0.46

Undifferentiated

6

2

  

2

6

 

Lymphatic invasion

Absent

24

11

 

0.42

17

22

0.8

Present

14

11

  

10

15

 

Venous invasion

Absent

13

9

 

0.78

10

16

0.8

Present

25

13

  

17

21

 

Tumor Stage

t0/t1

4

0

4

0.48

5

3

0.35

t2

9

5

  

7

7

 

t3

23

14

  

12

25

 

t4

2

3

  

3

2

 

N stage

n0

23

15

 

0.59

17

25

0.79

n1<

15

7

  

10

12

 

Pathological response

grade 0/1

25

17

 

0.29

18

24

0.63

grade 2

13

5

1

 

7

12

 

grade 3

0

0

3

 

2

1

 

Combined Chemotherapy

Not given

3

4

0

0.31

4

3

0.2

Given

35

18

4

 

23

34

 

Adjuvant chemotherapy

Given

16

5

 

0.13

9

12

0.99

Not Given

22

17

4

 

18

25

 

Recurrence

Present

11

11

 

0.16

6

16

0.11

Absent

27

11

4

 

21

21

 
  1. CD73 expression in tumor cells cannot be appropriately evaluated in 1 patient with a grade 2 response due to few remaining tumor cells as well as in 3 patients with grade 3 responses (pathological complete response). Statistical significance of the differences was evaluated by student-t-test, the Mann-Whitney test, the χ2-test and Fisher’s exact test