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Table 5 Intra-laboratory reproducibility and inter-laboratory agreement of individual genotype findings in SurePath screening samples

From: Clinical validation of full genotyping CLART® HPV4S assay on SurePath and ThinPrep collected screening samples according to the international guidelines for human papillomavirus test requirements for cervical screening

Assessment and Hr-HPV type No. of genotype findings per run or laboratory No. negative for both runs Kappa Value 95% Confidence Interval
Combined results First run Second run Lower Upper
Intra-laboratory reproducibility
 16 20 21 21 518 0.95 0.88 1.00
 18 3 4 3 536 0.86 0.58 1.00
 31 17 20 18 519 0.89 0.79 1.00
 33 4 5 5 534 0.80 0.52 1.00
 35 5 5 8 532 0.77 0.51 1.00
 39 12 14 15 523 0.82 0.67 0.98
 45 18 19 19 520 0.95 0.87 1.00
 51 7 11 8 528 0.73 0.51 0.96
 52 15 15 18 522 0.91 0.80 1.00
 56 12 12 12 528 1.00 1.00 1.00
 58 8 9 9 530 0.89 0.73 1.00
 59 9 9 11 529 0.90 0.76 1.00
 66 7 7 11 529 0.77 0.56 0.99
 68 1 3 1 537 0.50 −0.1 1.00
Inter-laboratory agreement
 16 17 21 18 518 0.87 0.75 0.98
 18 3 4 4 536 0.86 0.58 1.00
 31 15 20 16 519 0.83 0.69 0.96
 33 4 5 5 534 0.80 0.52 1.00
 35 5 5 7 533 0.83 0.60 1.00
 39 5 14 7 524 0.47 0.20 0.73
 45 13 19 13 520 0.78 0.62 0.94
 51 1 11 3 527 0.14 −0.11 0.38
 52 9 15 9 525 0.75 0.55 0.94
 56 3 12 4 527 0.37 0.07 0.67
 58 5 9 5 531 0.71 0.44 0.98
 59 3 9 4 530 0.46 0.12 0.80
 66 3 7 5 531 0.50 0.15 0.84
 68 1 3 2 536 0.40 −0.15 0.94