Prognostic implication and functional exploration for microRNA-20a as a molecular biomarker of gastrointestinal cancer

Table 1 Characteristics of the included articles

Author	Year	Country	Ethnicity	M/F	N	Age	Cancer type	TNM stage	Sample source	Methods	Endpoints	Median follow-up time	Hazard ratio
Schetter et al	2008	USA	Non-Asians	66/18	84	65	CRC	I-IV	Tissue	RT-PCR	OS	68	2.20 (1.10–4.60)
Ayerbes et al	2011	Spain	Non-Asians	25/13	38	63	GIC	I-IV	Tissue	RT-PCR	OS	22	1.07 (1.00–1.13)
Osawa et al	2011	Japan	Asians	26/11	37	65	GC	I-IV	Tissue	RT-PCR	OS	38	1.20 (1.12–1.58)
Kim et al	2012	Korea	Asians	57/34	91	61	GC	I-IV	Tissue	RT-PCR	OS	46	1.19 (0.83–1.69)
Wang et al	2012	China	Asians	43/22	65	60	GC	I-IV	Blood	RT-PCR	OS	36	1.58 (1.10–2.25)
Huang et al	2014	China	Asians	52/30	82	60	GC	I-IV	Blood	RT-PCR	OS	20	1.08 (1.02–1.15)
Chen et al	2015	China	Asians	NR	580	NR	CRC	I-IV	Tissue	RT-PCR	OS	NR	1.88 (1.09–3.23)
Cheng et al	2016	China	Asians	264/280	544	65	CRC	I-IV	Tissue	RT-PCR	OS	110	8.22 (4.47–15.12)
Yang et al	2017	China	Asians	35/20	55	60	GC	I-IV	Blood	RT-PCR	OS	34	2.30 (1.60–3.32)
Peng et al	2018	China	Asians	179/154	333	59	GC	I-III	Blood	RT-PCR	OS	36	2.07 (1.36–3.15)
Shao et al	2018	China	Asians	NR	NR	NR	GC	NR	Tissue	RT-PCR	OS	NR	1.02 (1.01–1.03)
Pesta et al.	2019	Czech	Non-Asians	18/10	28	NR	CRC	I-IV	Blood	RT-PCR	OS	36	1.67 (1.07–2.60)

Abbreviation: F Female, M Male, N Number, NR Not report, CRC Colorectal cancer, GC Gastric cancer, GIC Gastrointestinal cancer, OS Overall survival

ISSN: 1471-2407