A meta-analytic evaluation of the correlation between event-free survival and overall survival in randomized controlled trials of newly diagnosed Ewing sarcoma

Table 1 Correlations between surrogate endpoints and OS

Surrogate endpoint	R² (95% CI)	ρ (95% CI)	P-value
EFS	0.747 (0.513–0.981)	0.683 (0.035–0.927)	0.042
1-year EFS	0.348 (0.00–0.759)	0.450 (−0.305–0.858)	0.22
3-year EFS	0.765 (0.545–0.985)	0.717 (0.10–0.936)	0.030
5-year EFS	0.695 (0.423–0.967)	0.767 (0.209–0.948)	0.016
1-year OS	0.089 (0.00–0.408)	0.214 (−0.642–0.833)	0.64
3-year OS	0.831 (0.650–1.00)	0.929 (0.584–0.990)	0.0025
5-year OS	0.809 (0.625–0.993)	0.767 (0.209–0.948)	0.016

Abbreviations: CI confidence interval; OS overall survival; EFS event-free survival

ISSN: 1471-2407