Characteristics | Total (n = 26) No. of patients (%) | With Prophylactic PEG-G-CSF (n = 9) | Without Prophylactic PEG-G-CSF (n = 11) | No use of PEG-G-CSF (n = 6) |
---|---|---|---|---|
Age at enrollment, years | ||||
 Median | 53.5 | 51 | 58 | 40.5 |
 Range | 27–74 | 34–74 | 27–67 | 35–57 |
Gender | ||||
 Male | 13 (50.0) | 6 (66.7) | 3 (27.2) | 4 (66.7) |
 Female | 13 (50.0) | 3 (33.3) | 8 (72.3) | 2 (33.3) |
ECOG-PS | ||||
 /0 | 18 (69.2) | 8 (88.9) | 7 (63.6) | 3 (50.0) |
 /1 | 8 (30.8) | 1 (11.1) | 4 (36.4) | 3 (50.0) |
Primary location | ||||
 Right | 8 (30.8) | 5 (55.6) | 1 (9.0) | 2 (33.3) |
 Left | 18 (69.2) | 4 (44.4) | 10 (91.0) | 4 (66.7) |
Histology | ||||
 Diffuse | 5 (19.3) | 1 (11.1) | 3 (27.2) | 1 (16.7) |
 Intestinal | 21 (80.7) | 8 (88.9) | 8 (72.3) | 5 (83.3) |
Primary resection before chemotherapy | ||||
 Yes | 8 (30.8) | 3 (33.3) | 4 (36.4) | 1 (16.7) |
 No | 18 (69.2) | 6 (66.7) | 7 (63.6) | 5 (83.3) |
Diagnosis of metastasis | ||||
 Metachronous | 5 (19.3) | 3 (33.3) | 2 (18.2) | 0 (0) |
 Synchronous | 21 (80.7) | 6 (66.7) | 9 (81.8) | 6 (100) |
Metastatic site | ||||
 Liver | 23 (88.4) | 8 (88.9) | 9 (81.8) | 6 (100) |
 Lung | 7 (26.9) | 3 (33.3) | 4 (36.4) | 0 (0) |
 Lymph node | 16 (61.5) | 2 (22.2) | 8 (72.3) | 6 (100) |
 Peritoneum | 5 (19.3) | 0 (0) | 4 (36.4) | 1 (16.7) |
 Other | 3 (11.5) | 2 (22.2) | 1 (9.0) | 0 (0) |
Number of metastatic sites | ||||
 1 | 4 (15.4) | 2 (22.2) | 2 (18.2) | 0 (0) |
  ≥ 2 | 22 (84.6) | 7 (77.8) | 9 (81.8) | 6 (100) |
Previous adjuvant chemotherapy | ||||
 Yes | 2 (7.7) | 1 (11.1) | 1 (9.0) | 0 (0) |
 No | 24 (92.3) | 8 (88.9) | 10 (91.0) | 6 (100) |
RAS status | ||||
 Wild type | 3 (11.5) | 0 (0) | 2 (18.2) | 1 (16.7) |
 Mutant type | 23 (88.5) | 9 (100) | 9 (81.8) | 5 (83.3) |
UGT1A1 Status | ||||
 Wild type | 7 (26.9) | 3 (33.3) | 3 (27.2) | 1 (16.7) |
 *6 | 6 (23.0) | 2 (22.2) | 2 (18.2) | 2 (33.3) |
 *28 | 2 (7.7) | 0 (0) | 2 (18.2) | 0 (0) |
 Unknown | 11 (42.4) | 4 (44.5) | 4 (36.4) | 3 (50.0) |
CEA median, [range] | 88.0 [1.5–9205] | 12.2 [4.6–5638] | 155.9 [5–25,873] | 155.9 [5–25,873] |
CA19–9 median, [range] | 75.4 [2–50,000] | 99.7 [5.9–50,000] | 40.2 [2.7–982] | 40.2 [2.7–982] |