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Fig. 5 | BMC Cancer

Fig. 5

From: Roles of DANCR/microRNA-518a-3p/MDMA ceRNA network in the growth and malignant behaviors of colon cancer cells

Fig. 5

Overexpression of MDM2 partially reverses the inhibition on CC cell behaviors induced by DANCR silencing. MDM2 overexpressing vector and the corresponding EV were transfected into HT29 and SW116 cells with stably silenced DANCR. a, MDM2 expression in cells determined using RT-qPCR; b, proliferation activity of HT29 and SW116 cells measured using MTT assay; c, the ratio of apoptotic cells determined by flow cytometry; d, migration and invasion abilities of cells evaluated using Transwell assays. Data are expressed as mean ± SD; in panels A, C and D, data were analyzed by one-way ANOVA, while data in panel B by two-way ANOVA, and Tukey’s multiple comparison test was applied for the post hoc test; *, p < 0.05

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