The association of depressive symptoms, personality traits, and sociodemographic factors with health-related quality of life and quality of life in patients with advanced-stage lung cancer: an observational multi-center cohort study

Table 4 Results of the multivariable regression analyses for the WHOQOL-BREF (p < 0.05)

Independent variables	N	B	SE	β	P-value	Corrected P-value_a	95% CI for B	R²
	General facet
Age	117	−0.041	0.015	−0.232	0.006	0.024	−0.070, − 0.012	0.402
CES-D		−0.133	0.021	−0.625	< 0.001	< 0.001	−0.175, − 0.091
Physical health
ECOG: 0 to 1 versus 2 or higher	117	−2.747	0.751	−0.262	< 0.001	< 0.001	−4.234, −1.259	0.517
CES-D		−0.221	0.035	−0.542	< 0.001	< 0.001	−0.291, − 0.151
NEO-FFI conscientiousness		0.111	0.045	0.201	0.016	0.043	0.021, 0.200
	Psychological health
CES-D	117	−0.163	0.025	−0.534	< 0.001	0.000	−0.213, − 0.113	0.554
	Social relationships
Gender	119	1.107	0.467	0.222	0.020	0.080	0.181, 2.032	0.204
Partner status: no partner versus having a partner		1.428	0.588	0.216	0.017	0.080	0.262, 2.594
	Environment
CES-D	116	−0.063	0.028	−0.224	0.026	0.091	−0.118, − 0.008	0.375
STAI Trait		−0.163	0.049	−0.392	0.001	0.007	−0.259, − 0.066

_aBenjamini-Hochberg method was used to correct P-values
Abbreviations: WHOQOL-BREF World Health Organization Quality of Life-BREF questionnaire, N number of patients, B unstandardized beta, SE standard error, β standardized beta, CI confidence interval, R² explained varriance, CES-D Center for Epidemiologic Studies Depression Scale, ECOG Eastern Cooperative Oncology Group, NEO-FFI Neuroticism-Extraversion-Openness-Five Factor Inventory questionnaire, STAI, State Trait Anxiety Inventory

ISSN: 1471-2407