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Table 2 Comparisons of IDH1/2 mutations in ICCs between DNA sequencing and IHC methods

From: Distinct clinical and prognostic implication of IDH1/2 mutation and other most frequent mutations in large duct and small duct subtypes of intrahepatic cholangiocarcinoma

DNA sequencingMsMab-1 staining
Mutant geneNucleotide changeAmino acid changeNumberPositveNegativeReactivity by manual
IDH1CGT > TGTR132C615No
IDH1CGT > GGTR132G541Yes
IDH1CGT > CATR132H440Yes
IDH1CGT > CTTR132L211No
IDH2AGG > TGGR172W211Yes
IDH2AGG > AAGR172K202No
Wild type  1093106No