Table 1 Demographic characteristics of hypopharynx and larynx squamous cell carcinoma
Characteristics | All patients n (%) | Characteristics | All patients n (%) |
|---|---|---|---|
Total | 209 (100) | Â | Â |
Age (years) | Â | pT-classification | Â |
 Median (range) | 64.0 (30–88) | pT1 | 71 (34.0) |
 < 65 | 114 (54.5) | pT2 | 58 (27.8) |
 ≥ 65 | 95 (45.5) | pT3 | 52 (24.9) |
Gender | Â | pT4a | 28 (13.4) |
 Female | 14 (6.7) | pN-classification |  |
 Male | 195 (93.3) | pN0 | 118 (56.5) |
Primary sites | Â | pN1 | 13 (6.2) |
 Hypopharynx | 54 (25.8) | pN2 | 26 (12.5) |
 Larynx | 155 (74.2) | pN3 | 52 (24.9) |
Smoking | Â | Pathological stage | Â |
 Never smoker | 23 (11.0) | Stage I | 60 (28.7) |
 Former smoker | 54 (25.8) | Stage II | 29 (13.9) |
 Current smoker | 132 (63.2) | Stage III | 32 (15.3) |
Alcohol | Â | Stage IVA | 36 (17.2) |
 Non- or social- drinker | 45 (20.1) | Stage IVB | 52 (24.9) |
 Heavy drinker | 167 (79.9) | Adjuvant treatment |  |
Histologic differentiation | Â | No | 89 (42.6) |
 Well differentiated | 64 (30.6) | Yes | 120 (57.4) |
 Moderately differentiated | 123 (58.9) | Chemotherapy (C) | 0 (0.0) |
 Poorly differentiated | 22 (10.5) | Radiation therapy (R) | 71 (34.0) |
Lymphovascular invasion |  | C + R | 49 (23.4) |
 Absent | 163 (78.0) | Recurrence |  |
 Present | 46 (22.0) | No | 164 (78.5) |
Perineural invasion | Â | Yes | 45 (21.5) |
 Absent | 178 (85.2) | Local recurrence only | 23 (51.1) |
 Present | 31 (14.8) | Distant recurrence | 22 (48.9) |
Positive resection margin | Â | Disease-free survival | Â |
 Absent | 155 (74.2) | Mean (range; months) | 82.3 (2–105) |
 Present | 54 (25.8) | Overall survival time |  |
p16 status (n = 171) |  | Mean (range; months) | 76.4 (2–105) |
 Negative | 149 (87.1) |  |  |
 Positive | 22 (12.9) |  |  |