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Table 1 Demographic characteristics of hypopharynx and larynx squamous cell carcinoma

From: Prognostic implications of Fibroblast growth factor receptor 1 (FGFR1) gene amplification and protein overexpression in hypopharyngeal and laryngeal squamous cell carcinoma

CharacteristicsAll patients
n (%)
CharacteristicsAll patients
n (%)
Total209 (100)  
Age (years) pT-classification 
 Median (range)64.0 (30–88)pT171 (34.0)
 < 65114 (54.5)pT258 (27.8)
 ≥ 6595 (45.5)pT352 (24.9)
Gender pT4a28 (13.4)
 Female14 (6.7)pN-classification 
 Male195 (93.3)pN0118 (56.5)
Primary sites pN113 (6.2)
 Hypopharynx54 (25.8)pN226 (12.5)
 Larynx155 (74.2)pN352 (24.9)
Smoking Pathological stage 
 Never smoker23 (11.0)Stage I60 (28.7)
 Former smoker54 (25.8)Stage II29 (13.9)
 Current smoker132 (63.2)Stage III32 (15.3)
Alcohol Stage IVA36 (17.2)
 Non- or social- drinker45 (20.1)Stage IVB52 (24.9)
 Heavy drinker167 (79.9)Adjuvant treatment 
Histologic differentiation No89 (42.6)
 Well differentiated64 (30.6)Yes120 (57.4)
 Moderately differentiated123 (58.9)Chemotherapy (C)0 (0.0)
 Poorly differentiated22 (10.5)Radiation therapy (R)71 (34.0)
Lymphovascular invasion C + R49 (23.4)
 Absent163 (78.0)Recurrence 
 Present46 (22.0)No164 (78.5)
Perineural invasion Yes45 (21.5)
 Absent178 (85.2)Local recurrence only23 (51.1)
 Present31 (14.8)Distant recurrence22 (48.9)
Positive resection margin Disease-free survival 
 Absent155 (74.2)Mean (range; months)82.3 (2–105)
 Present54 (25.8)Overall survival time 
p16 status (n = 171) Mean (range; months)76.4 (2–105)
 Negative149 (87.1)  
 Positive22 (12.9)