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Table 1 Demographic characteristics of hypopharynx and larynx squamous cell carcinoma

From: Prognostic implications of Fibroblast growth factor receptor 1 (FGFR1) gene amplification and protein overexpression in hypopharyngeal and laryngeal squamous cell carcinoma

Characteristics All patients
n (%)
Characteristics All patients
n (%)
Total 209 (100)   
Age (years)   pT-classification  
 Median (range) 64.0 (30–88) pT1 71 (34.0)
 < 65 114 (54.5) pT2 58 (27.8)
 ≥ 65 95 (45.5) pT3 52 (24.9)
Gender   pT4a 28 (13.4)
 Female 14 (6.7) pN-classification  
 Male 195 (93.3) pN0 118 (56.5)
Primary sites   pN1 13 (6.2)
 Hypopharynx 54 (25.8) pN2 26 (12.5)
 Larynx 155 (74.2) pN3 52 (24.9)
Smoking   Pathological stage  
 Never smoker 23 (11.0) Stage I 60 (28.7)
 Former smoker 54 (25.8) Stage II 29 (13.9)
 Current smoker 132 (63.2) Stage III 32 (15.3)
Alcohol   Stage IVA 36 (17.2)
 Non- or social- drinker 45 (20.1) Stage IVB 52 (24.9)
 Heavy drinker 167 (79.9) Adjuvant treatment  
Histologic differentiation   No 89 (42.6)
 Well differentiated 64 (30.6) Yes 120 (57.4)
 Moderately differentiated 123 (58.9) Chemotherapy (C) 0 (0.0)
 Poorly differentiated 22 (10.5) Radiation therapy (R) 71 (34.0)
Lymphovascular invasion   C + R 49 (23.4)
 Absent 163 (78.0) Recurrence  
 Present 46 (22.0) No 164 (78.5)
Perineural invasion   Yes 45 (21.5)
 Absent 178 (85.2) Local recurrence only 23 (51.1)
 Present 31 (14.8) Distant recurrence 22 (48.9)
Positive resection margin   Disease-free survival  
 Absent 155 (74.2) Mean (range; months) 82.3 (2–105)
 Present 54 (25.8) Overall survival time  
p16 status (n = 171)   Mean (range; months) 76.4 (2–105)
 Negative 149 (87.1)   
 Positive 22 (12.9)