Fig. 4

Drug response shown in three patient-derived xenograft (PDX) models. a YHIM-3006 was established from a tongue cancer patient who was treated with pan-HER inhibitor and showed stable disease for 5 months. Afatinib treatment produced substantial tumor regression in YHIM-3006, which was concordant with the clinical response in the matched patient. b YHIM-3011 was treated with pan-HER inhibitor and showed significant tumor regression, which recapitulated the drug response of the corresponding patient who showed a partial response for more than 8 months. c YHIM-3004 was treated with pan-PI3K inhibitor and represented abrupt increase of multiple lymphnode, that mimicked the treatment response of the matched patient showing a progression after 1 month of BKM120 therapy