MTHFR, XRCC1 and OGG1 genetic polymorphisms in breast cancer: a case-control study in a population from North Sardinia

Table 2 Clinicopathological features of BC patients

Variables of BC (n. = 135)		n.	(%)
Age at diagnosis (mean years)		52.15
≤ 40		22	16.30
> 40		113	83.70
Family BC
Sporadic		76	56.30
Familial		59	43.70
Laterality
Bilateral		11	8.15
Unilateral		124	91.85
Menopausal status (at diagnosis)
premenopausal		72	53.33
postmenopausal		63	46.66
Histologic type
IDC		115	85.18
ILC		10	7.40
D or L in situ		7	5.18
Other		3	2.22
Histologic grade
G1		12	8.89
G2		79	58.52
G3		43	31.85
missing		1	0.74
Hormonal receptor
ER	pos	98	72.59
ER	neg	37	27.41
PgR	pos	91	67.40
PgR	Neg	44	32.60
Her-2
pos		42	31.11
neg		88	65.18
missing		5	3.70
Ki67
≤ 30%		103	76.30
> 30%		31	22.96
missing		1	0.74
Tumor size (T)
T0-Tis		7	5.18
T1-T2		96	71.11
T3-T4		32	23.70
Lymph nodes grade (N)
N0		59	43.70
N1		40	29.62
N2		19	14.08
N3		7	5.18
Nx		10	7.41
Distant Metastasis
M0		111	82.22
M1		22	16.30
missing		2	1.48
Clinical stages
0		12	8.88
I		43	31.85
II		34	25.18
III		19	14.10
IV		21	15.55
missing		6	4.44
Luminal A		57	42.22
Luminal B-like Her-2 neg		21	15.55
Luminal B-like Her-2 pos		21	15.55
Her-2 overexpressing		21	15.55
Triple negative		15	11.11

ISSN: 1471-2407