Arm A | Arm B | |||||||
---|---|---|---|---|---|---|---|---|
First-line (Cap+Bev) N = 37 | Second-line (Eve+Exe) N = 17 | First-line (Eve+Exe) N = 37 | Second-line (Cap+Bev) N = 19 | |||||
Any grade | Grade 3/4 | Any grade | Grade 3/4 | Any grade | Grade 3/4 | Any grade | Grade 3/4 | |
Adverse event, n (%) | ||||||||
Anemia | 1 (2.7%) | 4 (23.5%) | 5 (13.5%) | |||||
Arthralgia | 5 (13.5%) | 4 (10.8%) | 1 (5.3%) | |||||
Bone pain | 3 (8.1%) | 6 (16.2%) | ||||||
Cough | 5 (13.5%) | 3 (17.6%) | 6 (16.2%) | 2 (10.5%) | ||||
Decreased appetite | 6 (16.2%) | 1 (5.9%) | 5 (13.5%) | |||||
Diarrhea | 12 (32.4%) | 2 (11.8%) | 11 (29.7%) | 5 (26.3%) | ||||
Dyspnea | 6 (16.2%) | 3 (17.6%) | 4 (10.8%) | 4 (21.1%) | ||||
Fatigue | 13 (35.1%) | 3 (17.6%) | 6 (16.2%) | 2 (10.5%) | ||||
Hand-Foot Syndrome | 21 (56.8%) | 7 (18.9%) | 1 (2.7%) | 6 (31.6%) | 2 (10.5%) | |||
Headache | 6 (16.2%) | 6 (16.2%) | ||||||
Hypertension | 11 (29.7%) | 5 (13.5%) | 2 (5.4%) | 3 (15.8%) | ||||
Mucosal inflammation | 4 (10.8%) | 2 (11.8%) | 7 (18.9%) | |||||
Nausea | 15 (40.5%) | 1 (5.9%) | 9 (24.3%) | 5 (26.3%) | ||||
Edema peripheral | 2 (5.4%) | 6 (16.2%) | 2 (10.5%) | |||||
Pain | 2 (5.4%) | 2 (11.8%) | 2 (11.8%) | 1 (2.7%) | ||||
Pleural effusion | 2 (5.4%) | 2 (5.4%) | 3 (15.8%) | |||||
Pneumonia | 2 (11.8%) | 3 (8.1%) | ||||||
PSN | 6 (16.2%) | 1 (2.7%) | 2 (10.5%) | |||||
Stomatitis | 9 (24.3%) | 1 (5.9%) | 5 (13.5%) | 1 (5.3%) |