Table 3 Rates of patients’ preferencea (mITT/ITT/PP population)
mITT | Arm A (N = 5) | Arm B (N = 8) | Total (N = 13) | |||
|---|---|---|---|---|---|---|
n (%) | 95%-CI | n (%) | 95%-CI | n (%) | 95%-CI | |
Cap+Bev | 2 (40.0%) | [5.3, 85.3] | 6 (75.0%) | [34.9, 96.8] | 8 (61.5%) | [31.6, 86.1] |
Eve+Exe | 1 (20.0%) | [0.5, 71.6] | 1 (12.5%) | [0.3, 52.7] | 2 (15.4%) | [1.9, 45.4] |
I cannot decide | 2 (40.0%) | [5.3, 85.3] | 1 (12.5%) | [0.3, 52.7] | 3 (23.1%) | [5.0, 53.8] |
p-value (Chi-square) | 0.1653 | |||||
ITT | Arm A (N = 39) | Arm B (N = 38) | Total (N = 77) | |||
n (%) | 95%-CI | n (%) | 95%-CI | n (%) | 95%-CI | |
Cap+Bev | 3 (7.7%) | [1.6, 20.9] | 10 (26.3%) | [13.4, 43.1] | 13 (16.9%) | [9.3, 27.1] |
Eve+Exe | 5 (12.8%) | [4.3, 27.4] | 2 (5.3%) | [0.6, 17.7] | 7 (9.1%) | [3.7, 17.8] |
I cannot decide | 3 (7.7%) | [1.6, 20.9] | 4 (10.5%) | [2.9, 24.8] | 7 (9.1%) | [3.7, 17.8] |
Not evaluable | 2 (5.1%) | [0.6, 17.3] | 2 (5.3%) | [0.6, 17.7] | 4 (5.2%) | [1.4, 12.8] |
Item / questionnaire not answered | 4 (10.3%) | [2.9, 24.2] | 1 (2.6%) | [0.1, 13.8] | 5 (6.5%) | [2.1, 14.5] |
No second-line therapy | 22 (56.4%) | [39.6, 72.2] | 19 (50.0%) | [33.4, 66.6] | 41 (53.2%) | [41.5, 64.7] |
PP | Arm A (N = 13) | Arm B (N = 18) | Total (N = 31) | |||
n (%) | 95%-CI | n (%) | 95%-CI | n (%) | 95%-CI | |
Cap+Bev | 3 (23.1%) | [5.0, 53.8] | 10 (55.6%) | [30.8, 78.5] | 13 (41.9%) | [24.5, 60.9] |
Eve+Exe | 5 (38.5%) | [13.9, 68.4] | 2 (11.1%) | [1.4, 34.7] | 7 (22.6%) | [9.6, 41.1] |
I cannot decide | 3 (23.1%) | [5.0, 53.8] | 4 (22.2%) | [6.4, 47.6] | 7 (22.6%) | [9.6, 41.1] |
Not evaluable | 2 (15.4%) | [1.9, 45.4] | 2 (11.1%) | [1.4, 34.7] | 4 (12.9%) | [3.6, 29.8] |