Fig. 6
From: HOXB4 promotes the malignant progression of ovarian cancer via DHDDS
Effect of HOXB4 on the growth and metastasis of OV cells in vivo. a Representative images of tumors in the OVCAR3/scramble, OVCAR3/HOXB4, OVCAR3/DHDDS, and OVCAR3/HOXB4 + DHDDS-KD groups (n = 6 per group). b Tumor volume was recorded over time, and HOXB4 and DHDDS overexpression promoted tumor growth. Quantification of fluorescence in metastatic tumors (P < 0.01). c H&E staining of metastatic tumors in lung tissues and node counts; HOXB4 and DHDDS promoted lung metastasis. d Kaplan–Meier survival analysis of mice in different groups. e IHC staining of tumor samples and staining intensity analysis of the positive area to detect the progression markers for each group. Statistically significant differences were analyzed using one-way ANOVA