Expression and clinical significance of miR-4516 and miR-21-5p in serum of patients with colorectal cancer

BMC Cancer

Table 1 Relationship between the expression of miRNAs and clinicopathological characteristics of colorectal cancer

Group	N = 80	miR-4516		miR-21-5p
Group	N = 80	Relative Expression Level [M (P₂₅, P₇₅)]	P	Relative Expression Level [M (P₂₅, P₇₅)]	P
Age
< 60	43	2.09 (1.89, 2.25)	0.0969	1.75 (1.54, 2.01)	0.2768
≥ 60	37	2.08 (1.95, 2.16)	0.0969	1.83 (1.65, 2.03)	0.2768
Gender
male	38	2.14 (1.95, 2.24)	0.8576	1.74 (1.55, 1.96)	0.1522
female	42	2.11 (1.96, 2.27)	0.8576	1.84 (1.64, 2.04)	0.1522
Tumor Size
< 5 cm	35	2.10 (1.96, 2.26)	0.7774	1.74 (1.53, 1.94)	0.4806
≥ 5 cm	45	2.04 (1.95, 2.24)	0.7774	1.80 (1.62, 1.96)	0.4806
Tumor Location
colon	38	2.12 (1.97, 2.29)	0.5136	1.68 (1.53, 1.90)	0.4000
rectum	42	2.15 (1.99, 2.22)	0.5136	1.78 (1.55, 1.96)	0.4000
Infiltration Degree
T1,T2	30	1.94 (1.88, 1.98)	0.0432	1.76 (1.59, 1.92)	0.0758
T3,T4	50	2.17 (2.07, 2.26)	0.0432	1.79 (1.54, 1.94)	0.0758
TNM Stage
I-II	44	2.40 (2.20,2.48)	< 0.001	2.04 (1.90,2.19)	0.001
III-IV	36	1.79 (1.74, 1.92)	< 0.001	1.58 (1.35, 1.64)	0.001
Lymph Node Metastasis
non	48	2.33 (2.14, 2.39)	0.002	2.04 (1.90,2.19)	0.003
exist	32	1.80 (1.82, 1.90)	0.002	1.58 (1.35, 1.64)	0.003
Distant Metastasis
non	52	2.37 (2.20, 2.42)	0.029	1.64 (1.50, 1.88)	0.301
exist	28	1.81 (1.74, 1.89)	0.029	1.77 (1.58, 1.96)	0.301
CEA Level (ng/ml)
< 5	41	2.09 (1.97, 2.20)	0.417	1.88 (1.68, 1.92)	0.064
≥ 5	39	2.12 (1.99, 2.24)	0.417	1.60 (1.59, 1.79)	0.064

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