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Fig. 6 | BMC Cancer

Fig. 6

From: Hypoxic induction of vasculogenic mimicry in hepatocellular carcinoma: role of HIF-1 α, RhoA/ROCK and Rac1/PAK signaling

Fig. 6

Schematic overview summarizing the functional significance and regulation of RhoA/ROCK, Rac1/PAK and HIF-1α exposed to hypoxia in HCC. Hypoxia triggers the upregulation of RhoA/ROCK2 and Rac1/PAK, subsequently modulates HIF-1α stabilization, leading to elevated Vimentin expression with phosphorylation at Ser72 and Ser56, which finally induces VM development via promoting the secretion of VE-cadherin accompany occurrences of EMT (Epithelial cell transform to Mesenchymal cell) in hypoxia

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BMC Cancer

ISSN: 1471-2407

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