Table 2 Patient’s characteristics according to the expression of individual NER proteins in primary tumour (n = 207)
From: Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours
| Â | Â | ERCC1 | XPF | XPA | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Variable | N | Mean HS | SEM | Median | p value | Mean HS | SEM | Median | p value | Mean HS | SEM | Median | p value |
All patients | 207 | 13.5 | 2.9 | 0.0 | NA | 213.4 | 6.2 | 220.0 | NA | 51.6 | 4.5 | 20.0 | NA |
Histology | |||||||||||||
 Seminoma | 38 | 1.9 | 6.8 | 0.0 | 0.0807 | 163.0 | 13.8 | 200.0 | ***0.0015 | 31.9 | 10.5 | 5.0 | *0.0196 |
 Non-seminoma | 169 | 15.9 | 3.2 | 0.0 |  | 224.6 | 6.6 | 240.0 |  | 56.0 | 5.0 | 30.0 |  |
Tumour primary | |||||||||||||
 Primary TGCTs | 200 | 13.5 | 2.9 | 0.0 | 0.4771 | 212.2 | 6.2 | 210.0 | 0.2250 | 50.8 | 4.6 | 20.0 | 0.0676 |
 Extragonadal GCTs | 7 | 12.9 | 15.6 | 0.0 |  | 248.3 | 35.6 | 300.0 |  | 79.2 | 26.3 | 80.0 |  |
IGCCCG risk group | |||||||||||||
 Good prognosis | 158 | 9.9 | 3.3 | 0.0 | *0.0322 | 210.5 | 7.0 | 215.0 | 0.3983 | 44.7 | 5.0 | 10.0 | ***0.0002 |
 Intermediate | 23 | 21.3 | 8.5 | 0.0 |  | 239.8 | 18.2 | 265.0 |  | 60.2 | 13.1 | 50.0 |  |
 Poor prognosis | 26 | 28.2 | 8.2 | 0.0 |  | 206.0 | 17.4 | 200.0 |  | 91.8 | 13.4 | 75.0 |  |
Number of metastatic sites | |||||||||||||
 0 | 54 | 13.4 | 5.6 | 0.0 | 0.5566 | 216.3 | 11.9 | 210.0 | 0.8651 | 49.3 | 8.7 | 20.0 | 0.0628 |
 1 to 2 | 124 | 11.9 | 3.7 | 0.0 |  | 210.3 | 8.0 | 210.0 |  | 47.0 | 5.7 | 20.0 |  |
  > 3 | 29 | 20.6 | 7.9 | 0.0 |  | 220.2 | 16.6 | 250.0 |  | 82.5 | 13.0 | 55.0 |  |
Retroperitoneal lymph nodes metastases | |||||||||||||
 Absent | 61 | 13.4 | 5.3 | 0,0 | 0.5226 | 215.4 | 11.2 | 210.0 | 0.8157 | 53.9 | 8.3 | 20.0 | 0.7993 |
 Present | 146 | 13.5 | 3.4 | 0.0 |  | 212.4 | 7.4 | 220.0 |  | 50.6 | 5.4 | 20.0 |  |
Mediastinal lymph nodes metastases | |||||||||||||
 Absent | 189 | 12.8 | 3.0 | 0.0 | 0.9408 | 213.3 | 6.5 | 215.0 | 0.9501 | 50.2 | 4.7 | 20.0 | 0.4597 |
 Present | 18 | 21.2 | 10.0 | 0.0 |  | 213.1 | 20.6 | 225.0 |  | 72.7 | 16.6 | 75.0 |  |
Lung metastases | |||||||||||||
 Absent | 160 | 10.9 | 3.3 | 0.0 | 0.1664 | 208.6 | 7.0 | 205.0 | 0.1478 | 47.6 | 5.1 | 10.0 | *0.0252 |
 Present | 47 | 22.3 | 6.0 | 0.0 |  | 229.2 | 12.8 | 257.5 |  | 67.0 | 9.7 | 50.0 |  |
Liver | |||||||||||||
 Absent | 197 | 12.7 | 2.9 | 0.0 | 0.0510 | 213.0 | 6.3 | 210.0 | 0.8140 | 49.1 | 4.6 | 20.0 | ***0.0037 |
 Present | 10 | 28.0 | 13.0 | 0.0 |  | 219.0 | 27.7 | 250.0 |  | 110.6 | 21.1 | 120.0 |  |
Non-pulmonary visceral metastases | |||||||||||||
 Absent | 194 | 13.2 | 3.0 | 0.0 | 0.2293 | 213.1 | 6.4 | 210.0 | 0.9441 | 49.0 | 4.6 | 20.0 | ***0.0032 |
 Present | 13 | 16.5 | 11.4 | 0.0 |  | 216.2 | 24.3 | 230.0 |  | 101.4 | 19.1 | 70.0 |  |
S stage | |||||||||||||
 0 | 78 | 9.3 | 4.6 | 0.0 | *0.0455 | 198.9 | 9.7 | 200.0 | 0.3526 | 38.5 | 7.1 | 5.0 | ***0.0004 |
 1 | 78 | 6.9 | 4.6 | 0.0 |  | 218.9 | 9.8 | 240.0 |  | 51.6 | 7.1 | 20.0 |  |
 2 | 29 | 29.7 | 7.5 | 0.0 |  | 232.9 | 16.0 | 250.0 |  | 61.9 | 12.1 | 50.0 |  |
 3 | 16 | 36.6 | 10.1 | 0.0 |  | 226.0 | 22.2 | 240.0 |  | 102.3 | 16.2 | 100.0 |  |
 unknown | 6 |  |  |  |  |  |  |  |  |  |  |  |  |